{"id":"W2116612156","doi":"10.1128/aac.47.7.2376-2379.2003","title":"The M184V Substitution in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Delays the Development of Resistance to Amprenavir and Efavirenz in Subtype B and C Clinical Isolates","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Amprenavir; Efavirenz; Virology; Reverse transcriptase; Resistance mutation; Reverse-transcriptase inhibitor; Biology; Human immunodeficiency virus (HIV); Drug resistance; Medicine; Viral disease; Sida; Microbiology; Polymerase chain reaction; Viral load; Genetics; Enzyme; Protease; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634502,0.0001865645,0.0002243941,0.0001863666,0.0002259263,0.000304921,0.0001970418,0.0003635494,0.0009985327],"category_scores_gemma":[0.0005008503,0.0001887663,0.0002056475,0.0001065642,0.0001451563,0.0001500987,0.00008792515,0.000445078,0.0003099136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236626,"about_ca_system_score_gemma":0.0002419521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007554726,"about_ca_topic_score_gemma":0.00113729,"domain_scores_codex":[0.9997504,0.0000729186,0.00003729511,0.00002881275,0.00006347967,0.00004705434],"domain_scores_gemma":[0.9998634,0.0000404457,0.00003968134,0.00001186271,0.00001393925,0.00003064155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009155876,0.0002823215,0.006436959,0.00004481086,0.0000288082,0.0007175216,0.00004778205,0.0004496304,0.9799531,0.000265011,0.0002952718,0.0105632],"study_design_scores_gemma":[0.0003160101,0.005418622,0.04846463,0.00002715773,0.00007913853,0.00878421,0.0001121734,0.005546214,0.9255675,0.0001869196,0.005477144,0.00002034071],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989863,0.0003382289,0.0002174665,0.00003792436,0.00001453951,0.0000113571,0.00006125274,0.00001130563,0.0003216149],"genre_scores_gemma":[0.9977969,0.0002022417,0.001103879,0.00003643728,0.00001255799,0.0000128279,0.0002053294,0.000008322379,0.0006214832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009985327,"threshold_uncertainty_score":0.003340423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333159081078934,"score_gpt":0.3029249594230058,"score_spread":0.2795933686122165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}