{"id":"W2116648459","doi":"10.1038/mtna.2013.50","title":"Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Internal ribosome entry site; Luciferase; In vivo; Gene expression; Molecular biology; Hepatitis C virus; Gene; Biology; Messenger RNA; Virology; Virus; Transfection; Biochemistry; Translation (biology); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001148113,0.0003114459,0.0003211797,0.0001090401,0.00005918261,0.00003748541,0.0003256787,0.0002275207,0.00007621916],"category_scores_gemma":[0.00002490437,0.0002531388,0.0001426795,0.0001760399,0.0001265398,0.00002071982,0.0001059935,0.0001271453,0.00002869822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002628709,"about_ca_system_score_gemma":0.00004664581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004179493,"about_ca_topic_score_gemma":0.00008551158,"domain_scores_codex":[0.9982835,0.0001295185,0.0004394251,0.0005000939,0.000255161,0.0003923167],"domain_scores_gemma":[0.9989951,0.00001089722,0.0002124934,0.0005028155,0.0001659651,0.0001127059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003875984,0.0002289579,0.0101815,0.00001556786,0.0000845368,0.00002740738,0.0001527118,0.0002049447,0.9831612,0.000002425301,0.0001461208,0.005407048],"study_design_scores_gemma":[0.001214371,0.001019824,0.01638262,0.0001412242,0.00001500571,0.0000152167,0.0001050301,0.0002273795,0.980074,0.00003094546,0.000448965,0.0003253648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972525,0.001601079,0.0003426444,0.0001239349,0.00008240515,0.000474159,0.00001679172,0.00002151223,0.00008498017],"genre_scores_gemma":[0.9968325,0.001306721,0.0012054,0.0003623399,0.00006138547,0.00007863046,0.00004305804,0.00006035,0.00004963583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006201117,"threshold_uncertainty_score":0.9999921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007279195911446764,"score_gpt":0.2083072658958608,"score_spread":0.201028069984414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}