{"id":"W2116648459","doi":"10.1038/mtna.2013.50","title":"Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Internal ribosome entry site; Luciferase; In vivo; Gene expression; Molecular biology; Hepatitis C virus; Gene; Biology; Messenger RNA; Virology; Virus; Transfection; Biochemistry; Translation (biology); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003582559,0.0004947567,0.0003624116,0.0004126588,0.0001342473,0.0002663211,0.0003040113,0.0005378523,0.00104892],"category_scores_gemma":[0.0001410096,0.000271501,0.0002977032,0.0001311823,0.0003455945,0.0002813557,0.0001915043,0.0006921359,0.0004519166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003802257,"about_ca_system_score_gemma":0.0002893917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004995076,"about_ca_topic_score_gemma":0.0008336095,"domain_scores_codex":[0.9997645,0.00004476274,0.00002288019,0.00005094807,0.00006671856,0.0000501603],"domain_scores_gemma":[0.9998555,0.00002025051,0.00005760751,0.00001335616,0.00001709823,0.00003627963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001240394,0.00004124286,0.00003481414,0.00002634524,0.000004425716,0.00001355718,0.000008513935,0.0001181692,0.9981029,0.0001665903,0.0000530196,0.001306454],"study_design_scores_gemma":[0.00004989442,0.0006592685,0.0004046723,0.000005915289,0.00001378779,0.00007246364,0.000005282639,0.001197224,0.9953819,0.0000519009,0.00215262,0.000005103768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661306,0.002642412,0.02507027,0.0003753565,0.0001310452,0.0002727177,0.0008965638,0.0007602503,0.003720794],"genre_scores_gemma":[0.9688088,0.002007808,0.01994438,0.0001688352,0.0000372045,0.0003198897,0.001064049,0.0001388723,0.007510275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104892,"threshold_uncertainty_score":0.003508985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007279195911446764,"score_gpt":0.2083072658958608,"score_spread":0.201028069984414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}