{"id":"W2116663251","doi":"10.1002/ardp.201200193","title":"Trimethyl‐4‐oxo‐4,5,6,7‐tetrahydroindazole‐1‐acetic Acid: A New Lead Compound with Selective COX‐2 Inhibitory Activity","year":2012,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Acetic acid; Chemistry; Lead compound; Cyclooxygenase; Enzyme; Stereochemistry; Selectivity; Active site; Inhibitory postsynaptic potential; Docking (animal); In vitro; Biochemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004937474,0.000485254,0.000667064,0.0002737691,0.0002209547,0.00003183494,0.0001650131,0.0001291709,0.000176265],"category_scores_gemma":[0.0001020022,0.0003917861,0.0001814793,0.0004026877,0.0002598425,0.0004375737,0.00008302781,0.001001382,0.000442265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000189919,"about_ca_system_score_gemma":0.0006364176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001003843,"about_ca_topic_score_gemma":0.00001944115,"domain_scores_codex":[0.9972228,0.0002732546,0.000308568,0.0004685387,0.0006565654,0.00107032],"domain_scores_gemma":[0.9979235,0.000377242,0.0001670552,0.0004651013,0.00007538122,0.0009917542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00623661,0.001988813,0.09321165,0.0006673911,0.001278286,0.0005497265,0.01042227,0.00002076779,0.7655208,0.0001281296,0.0620877,0.0578879],"study_design_scores_gemma":[0.01034742,0.0008932758,0.08310193,0.0002377786,0.0006980869,0.000847526,0.0001058681,0.0004942686,0.883424,0.00009051046,0.0190052,0.0007541432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869104,0.001256973,0.001152093,0.0004780448,0.0006320222,0.001057174,0.000012291,0.0002405541,0.008260437],"genre_scores_gemma":[0.994855,0.00003992831,0.001124665,0.0008600464,0.001984426,0.00005105676,0.00002800475,0.0001035736,0.000953266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1179033,"threshold_uncertainty_score":0.9998534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948360070648708,"score_gpt":0.2839430805097922,"score_spread":0.2644594798033051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}