{"id":"W2116663251","doi":"10.1002/ardp.201200193","title":"Trimethyl‐4‐oxo‐4,5,6,7‐tetrahydroindazole‐1‐acetic Acid: A New Lead Compound with Selective COX‐2 Inhibitory Activity","year":2012,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Acetic acid; Chemistry; Lead compound; Cyclooxygenase; Enzyme; Stereochemistry; Selectivity; Active site; Inhibitory postsynaptic potential; Docking (animal); In vitro; Biochemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099492,0.0004804284,0.0004727078,0.000367874,0.0001536346,0.0001673102,0.0005612284,0.0002922545,0.001358249],"category_scores_gemma":[0.00008632116,0.0001527944,0.0002066588,0.0002936731,0.0001625559,0.0001490878,0.0001739638,0.0004557176,0.0005569066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002295907,"about_ca_system_score_gemma":0.000351359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007019075,"about_ca_topic_score_gemma":0.002544145,"domain_scores_codex":[0.9999492,0.000008313061,0.000002942982,0.00001020667,0.00001043127,0.00001876077],"domain_scores_gemma":[0.999965,0.000002685952,0.000008922505,0.00000248426,0.000008485024,0.00001248297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004230807,0.0003126234,0.0003446027,0.0004661172,0.0000314934,0.000748382,0.000071547,0.001147286,0.9674274,0.0006800861,0.0007626201,0.02758472],"study_design_scores_gemma":[0.0008889358,0.009484406,0.00796082,0.0001012537,0.0002387789,0.003516508,0.00009345893,0.003976182,0.9214243,0.0003832644,0.0518505,0.00008147732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9029478,0.05645494,0.02544743,0.0008975727,0.0005038918,0.0006639223,0.001413399,0.0006201523,0.01105093],"genre_scores_gemma":[0.9481821,0.02100253,0.02111091,0.0003343217,0.0001187784,0.0002712958,0.001028195,0.00002582596,0.007925916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358249,"threshold_uncertainty_score":0.004543781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948360070648708,"score_gpt":0.2839430805097922,"score_spread":0.2644594798033051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}