{"id":"W2116668074","doi":"10.1038/ng.2250","title":"Identification of common variants associated with human hippocampal and intracranial volumes","year":2012,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":660,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; SickKids Foundation; Montreal Neurological Institute and Hospital; Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; University of California, San Diego; National Institutes of Health; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Ipsen; H. Lundbeck A/S; Servier; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Pfizer; Biogen; BioClinica; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Synarc; Cilag; Medpace; Eisai; Howard Hughes Medical Institute; Genentech; Alexander von Humboldt-Stiftung; Deutsche Forschungsgemeinschaft; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Alzheimer's Drug Discovery Foundation; GlaxoSmithKline; National Center for Advancing Translational Sciences; School of Medicine, University of New Mexico; Cure Alzheimer's Fund; AstraZeneca; U.S. Public Health Service; Eli Lilly and Company; Bristol-Myers Squibb; Siemens; TauRx Pharmaceuticals; Hôpitaux Universitaires de Genève; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hippocampal formation; Brain size; Genome-wide association study; Biology; Locus (genetics); Hippocampus; Magnetic resonance imaging; Human brain; Neuroscience; Single-nucleotide polymorphism; Genetics; Genotype; Gene; Medicine; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006008996,0.0007382407,0.000665349,0.002795258,0.000626527,0.0008995128,0.0008720385,0.001109869,0.003022775],"category_scores_gemma":[0.002663117,0.0004412982,0.001191414,0.002923836,0.0007380184,0.0003908834,0.0006872048,0.000904097,0.000205724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404832,"about_ca_system_score_gemma":0.0003232728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004989963,"about_ca_topic_score_gemma":0.004029838,"domain_scores_codex":[0.9990051,0.0001976342,0.0001750147,0.0003443478,0.0001806661,0.00009711838],"domain_scores_gemma":[0.9974554,0.001036137,0.0008524192,0.0002917268,0.0001818625,0.0001825175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002826786,0.0001632396,0.8808702,0.0001688978,0.003201569,0.007950844,0.000692385,0.001214027,0.08332483,0.001418562,0.0006001747,0.01756838],"study_design_scores_gemma":[0.0001045844,0.0001837289,0.9801801,0.00002830809,0.001155628,0.00823514,0.00021877,0.001440505,0.006341171,0.001267338,0.000806906,0.00003788384],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971041,0.0006518881,0.001096962,0.0001050108,0.00002098096,0.000006747898,0.00048763,0.00002954168,0.0004970973],"genre_scores_gemma":[0.9986846,0.00015361,0.0006457779,0.00002423838,0.00002522119,0.000004858803,0.0002309663,0.00001566796,0.00021508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004989963,"threshold_uncertainty_score":0.01011223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007762426884572167,"score_gpt":0.2682579960081517,"score_spread":0.2604955691235795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}