{"id":"W2116673443","doi":"10.1093/hmg/ddg156","title":"Huntingtin contains a highly conserved nuclear export signal","year":2003,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McMaster University Medical Centre","funders":"University of British Columbia; University of Tokyo; Hereditary Disease Foundation","keywords":"Huntingtin; Polyglutamine tract; Biology; Huntingtin Protein; Mutant; Nuclear localization sequence; Nuclear transport; Cell biology; Cell nucleus; Trinucleotide repeat expansion; Nuclear export signal; Nuclear protein; Mutation; Molecular biology; Nucleus; Genetics; Gene; Transcription factor; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001309932,0.0003297242,0.0002564201,0.00010934,0.0003464406,0.0001475913,0.00041977,0.00008599,0.000593131],"category_scores_gemma":[0.0003187977,0.0003705916,0.0001694001,0.0002354415,0.0002786458,0.00003607669,0.0001080398,0.000184692,0.000212501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003042875,"about_ca_system_score_gemma":0.0001119068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004219937,"about_ca_topic_score_gemma":0.000003817991,"domain_scores_codex":[0.9972141,0.0005273052,0.0004067705,0.0007866876,0.0005087078,0.0005564675],"domain_scores_gemma":[0.9987568,0.00006178968,0.0001588708,0.0006512948,0.000102653,0.0002686387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007730281,0.0001503119,0.001029069,0.00001005292,0.0000080718,0.0002128112,0.00009391564,0.0002925129,0.9760783,0.0216411,0.000430768,0.00004539113],"study_design_scores_gemma":[0.0007228261,0.0002209202,0.004343373,0.000009732737,0.0000392406,0.00003207277,0.00005369344,0.0001636569,0.984912,0.001356598,0.007743774,0.0004021272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896156,0.0001584517,0.0006327285,0.00006237291,0.0001312213,0.0004136553,0.00001722677,0.0001301429,0.008838653],"genre_scores_gemma":[0.9950305,0.0000163146,0.001146996,0.00328809,0.00003876719,0.00002616239,0.000005630611,0.0001035537,0.0003440013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0202845,"threshold_uncertainty_score":0.9998746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03543771730386804,"score_gpt":0.2644224857249721,"score_spread":0.228984768421104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}