{"id":"W2116714338","doi":"10.1161/circresaha.111.250464","title":"Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca <sup>2+</sup> Release and Cardiac Contractility, Independently of L-Type Ca <sup>2+</sup> Current","year":2011,"lang":"en","type":"article","venue":"Circulation Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Queen's University; University Health Network","funders":"National Institutes of Health; University of Toronto; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Endoplasmic reticulum; Contractility; Calcium; Internal medicine; Chemistry; Phosphodiesterase; Biophysics; Endocrinology; Medicine; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001760449,0.0003236178,0.0004063385,0.0002705533,0.0003694619,0.00009257952,0.0002337755,0.0003699609,0.0003751003],"category_scores_gemma":[0.0009709879,0.0003160069,0.0001553522,0.0004863086,0.0005514663,0.00005310698,0.0002527383,0.0004665449,0.00004488233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009288967,"about_ca_system_score_gemma":0.0003964486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000718877,"about_ca_topic_score_gemma":0.00002895698,"domain_scores_codex":[0.9964209,0.0007550824,0.0006684442,0.0008239127,0.0007569882,0.0005746546],"domain_scores_gemma":[0.9970479,0.0001507695,0.0001896581,0.0008246337,0.001451594,0.0003354662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01139767,0.003693862,0.5230458,0.002405753,0.001748145,0.0001134932,0.01618552,0.1608175,0.1632333,0.001489635,0.05275337,0.06311589],"study_design_scores_gemma":[0.006482757,0.001457375,0.1597297,0.0005206419,0.0003207336,0.0001085785,0.004410056,0.6034768,0.1817645,0.001447381,0.03847346,0.001808073],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939223,0.00375995,0.0005493336,0.00015998,0.000247885,0.0007735515,0.0001151513,0.00003073323,0.0004411097],"genre_scores_gemma":[0.9972258,0.000837728,0.000186451,0.00005882967,0.0002435008,0.00004727261,0.0008472081,0.00004739268,0.0005058827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4426593,"threshold_uncertainty_score":0.9999292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0427226054990063,"score_gpt":0.30889280429658,"score_spread":0.2661701987975737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}