{"id":"W2116714338","doi":"10.1161/circresaha.111.250464","title":"Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca <sup>2+</sup> Release and Cardiac Contractility, Independently of L-Type Ca <sup>2+</sup> Current","year":2011,"lang":"en","type":"article","venue":"Circulation Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Queen's University; University Health Network","funders":"National Institutes of Health; University of Toronto; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Endoplasmic reticulum; Contractility; Calcium; Internal medicine; Chemistry; Phosphodiesterase; Biophysics; Endocrinology; Medicine; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003160784,0.0005712272,0.0002978647,0.000265118,0.0002221108,0.0004021012,0.0004243258,0.000439365,0.001727563],"category_scores_gemma":[0.0002137552,0.0002926909,0.0003301546,0.000103891,0.0006852699,0.000338706,0.0003630458,0.0006190888,0.0004543579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005062509,"about_ca_system_score_gemma":0.0002818679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003134992,"about_ca_topic_score_gemma":0.000638728,"domain_scores_codex":[0.9998322,0.00002725371,0.00002472356,0.00005372742,0.00002827329,0.0000339035],"domain_scores_gemma":[0.999689,0.00003463594,0.0001482579,0.000032138,0.00001899293,0.0000770649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005125767,0.00004710356,0.001315614,0.00005302409,0.000006041054,0.00007181476,0.00001243733,0.00003195568,0.996789,0.00007760675,0.00004436645,0.001038444],"study_design_scores_gemma":[0.0001898116,0.001270833,0.03726672,0.00003070461,0.00006892414,0.0006836342,0.00008932266,0.0007417524,0.9566599,0.0001091861,0.002876041,0.00001325045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927902,0.002097338,0.002896892,0.000287718,0.00003526693,0.0000689239,0.000822878,0.00009903465,0.0009016708],"genre_scores_gemma":[0.9912357,0.001460216,0.003379283,0.0001420109,0.00002326133,0.0001655626,0.0008120441,0.00003921525,0.002742733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727563,"threshold_uncertainty_score":0.005779207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0427226054990063,"score_gpt":0.30889280429658,"score_spread":0.2661701987975737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}