{"id":"W2116745209","doi":"10.1371/journal.pone.0019018","title":"Progression to AIDS in South Africa Is Associated with both Reverting and Compensatory Viral Mutations","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Health Laboratory Service; International Development Research Centre; Wellcome Trust","keywords":"Viral load; ELISPOT; Biology; Virology; Immune system; Immunology; Viral evolution; Epitope; Viral replication; Reversion; Virus; T cell; Phenotype; Genetics; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003486696,0.0002904254,0.0002651507,0.0005622153,0.0006213411,0.0005622467,0.0001486409,0.0002527413,0.002167674],"category_scores_gemma":[0.001283431,0.0002210597,0.0001559297,0.0006089755,0.0007175701,0.000369329,0.0005588985,0.0003376347,0.0002002436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002755349,"about_ca_system_score_gemma":0.000363316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003440627,"about_ca_topic_score_gemma":0.005136467,"domain_scores_codex":[0.9998028,0.0000464735,0.0000148602,0.00004662177,0.00003118263,0.00005800795],"domain_scores_gemma":[0.9994554,0.0001163242,0.0002750071,0.00004181595,0.00004309431,0.00006834556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004049684,0.00005033646,0.9471795,0.0001434026,0.00006130117,0.001452253,0.002822877,0.0001340799,0.03170493,0.0003140175,0.0001295448,0.01560286],"study_design_scores_gemma":[0.000008453684,0.0002308487,0.9934963,0.00003590875,0.00002754483,0.002638461,0.001399698,0.0001425027,0.0009233563,0.0002986872,0.0007876057,0.00001076604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992006,0.0002622884,0.00009764628,0.00003536008,0.000001670286,0.000007872514,0.00004244945,0.000003059251,0.0003490104],"genre_scores_gemma":[0.9994857,0.0002374911,0.00009886328,0.0000141698,0.000003563621,0.000005264973,0.00003296764,0.000001648917,0.0001203058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003440627,"threshold_uncertainty_score":0.007251561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05706849504497036,"score_gpt":0.2548276713518461,"score_spread":0.1977591763068757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}