{"id":"W2116786392","doi":"10.1095/biolreprod.109.082578","title":"Tumor Necrosis Factor Stimulates Matrix Metalloproteinase 9 Secretion from Cultured Human Chorionic Trophoblast Cells Through TNF Receptor 1 Signaling to IKBKB-NFKB and MAPK1/3 Pathway1","year":2010,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Tumor necrosis factor alpha; Biology; Signal transduction; MAPK/ERK pathway; Phosphorylation; Kinase; Molecular biology; Receptor; Cell biology; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003140402,0.000310413,0.0003693324,0.00007485539,0.0001957127,0.00003079324,0.0002010104,0.0003716663,0.0001520225],"category_scores_gemma":[0.0002395489,0.0002863042,0.000134578,0.0001429415,0.0002199807,0.00001796657,0.0001329017,0.0002503506,0.00002131302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002262127,"about_ca_system_score_gemma":0.00004679988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003765153,"about_ca_topic_score_gemma":0.00004783657,"domain_scores_codex":[0.9977953,0.0001360579,0.000453383,0.001183911,0.0001234748,0.0003078567],"domain_scores_gemma":[0.9986197,0.00001847632,0.0003174848,0.0007109789,0.0002263251,0.000107004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001868955,0.00007822397,0.0005832525,0.00002594906,0.00008199979,8.983457e-7,0.0002410627,0.0000554415,0.9971732,0.00005343334,0.000182194,0.001337425],"study_design_scores_gemma":[0.0005038254,0.0007724076,0.0007440044,0.00002336432,0.00003669548,0.000008902099,0.00007651991,0.00000942824,0.9794815,0.0004292733,0.01760221,0.0003118882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955006,0.001085418,0.001346949,0.0001712829,0.0009931388,0.000587385,0.0002479978,0.00005532423,0.00001195411],"genre_scores_gemma":[0.9825804,0.00007964353,0.01528849,0.00003662144,0.001023482,0.00005272797,0.0006787488,0.00004171184,0.0002181986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01769174,"threshold_uncertainty_score":0.9999589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126686768959173,"score_gpt":0.2626163102434399,"score_spread":0.2499476333475226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}