{"id":"W2116786392","doi":"10.1095/biolreprod.109.082578","title":"Tumor Necrosis Factor Stimulates Matrix Metalloproteinase 9 Secretion from Cultured Human Chorionic Trophoblast Cells Through TNF Receptor 1 Signaling to IKBKB-NFKB and MAPK1/3 Pathway1","year":2010,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Tumor necrosis factor alpha; Biology; Signal transduction; MAPK/ERK pathway; Phosphorylation; Kinase; Molecular biology; Receptor; Cell biology; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472187,0.0006184691,0.0003335528,0.0002498285,0.0001713793,0.0002978207,0.0001280761,0.0002010561,0.001912405],"category_scores_gemma":[0.0002251878,0.0001966912,0.0003890537,0.000218347,0.000231652,0.0002423784,0.0002379316,0.0006428175,0.0006833842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003674419,"about_ca_system_score_gemma":0.0002508493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001560056,"about_ca_topic_score_gemma":0.001741696,"domain_scores_codex":[0.9997535,0.00005565516,0.00003338143,0.00003602116,0.00007231867,0.00004911321],"domain_scores_gemma":[0.9998776,0.00002977705,0.00002719565,0.00002133134,0.00001498699,0.00002908366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001594882,0.00001948488,0.000257758,0.00005152535,0.0000042001,0.0001451951,0.00002914391,0.00002215123,0.9986633,0.00002582391,0.00004094508,0.000580998],"study_design_scores_gemma":[0.00006326698,0.0006200458,0.007436637,0.00001226982,0.00001954701,0.0007499411,0.00007149779,0.0008994355,0.9866519,0.00006004949,0.003408507,0.00000692478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805876,0.008826844,0.006074009,0.0002945554,0.0001217409,0.000120986,0.001243031,0.0001216664,0.002609738],"genre_scores_gemma":[0.9840718,0.003855303,0.005803526,0.000101373,0.00005666455,0.0001378417,0.001671616,0.00001917468,0.004282692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001912405,"threshold_uncertainty_score":0.006397665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126686768959173,"score_gpt":0.2626163102434399,"score_spread":0.2499476333475226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}