{"id":"W2116788622","doi":"10.1016/j.bmcl.2003.08.055","title":"2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Anxiolytic; Trifluoromethyl; Receptor; Stereochemistry; Chemical synthesis; Antagonist; Pharmacology; In vitro; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002591555,0.0003835601,0.0005030888,0.0002500446,0.0003563914,0.0002052809,0.0006211545,0.0003563501,0.002129929],"category_scores_gemma":[0.0002355615,0.0002437334,0.0002338086,0.0003265466,0.0002301685,0.0003263981,0.0002244833,0.0005583577,0.0005793102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003181102,"about_ca_system_score_gemma":0.0002935004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002304564,"about_ca_topic_score_gemma":0.005519705,"domain_scores_codex":[0.9998913,0.00003140679,0.000005684624,0.0000130483,0.00001759013,0.00004088022],"domain_scores_gemma":[0.99992,0.00002214224,0.00001677105,0.000009622919,0.00001387009,0.00001758421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00125001,0.0002221486,0.0002784421,0.0003007417,0.00003133339,0.0003391659,0.0001420764,0.0009617539,0.9723002,0.0009845735,0.0007886984,0.02240069],"study_design_scores_gemma":[0.0007109226,0.01093042,0.006928477,0.00005534396,0.0001768433,0.001418926,0.0001185429,0.003396758,0.943302,0.0003354971,0.03254099,0.00008525891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501935,0.0264375,0.01339271,0.000409841,0.0001958049,0.0003444605,0.0008463538,0.0003690048,0.007810831],"genre_scores_gemma":[0.9700431,0.01623063,0.006223771,0.0001922417,0.00008269575,0.0001444635,0.000703425,0.00004002084,0.006339643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002304564,"threshold_uncertainty_score":0.007125378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05269348782834631,"score_gpt":0.3096372956092988,"score_spread":0.2569438077809525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}