{"id":"W2116792616","doi":"10.1186/1475-2875-11-131","title":"Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections","year":2012,"lang":"en","type":"article","venue":"Malaria Journal","topic":"Malaria Research and Control","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Toronto Public Health; University of Calgary","funders":"Fondazione Roma; King Abdullah University of Science and Technology","keywords":"Plasmodium falciparum; Artemether; Artemisinin; Dihydroartemisinin; Biology; Haplotype; Malaria; Artesunate; Parasitology; Genotype; Single-nucleotide polymorphism; Drug resistance; Genetics; Pharmacology; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001263438,0.0002409515,0.0004650445,0.00157244,0.0001135096,0.0001081013,0.0001431561,0.0001376794,0.000339195],"category_scores_gemma":[0.0003686546,0.0001916813,0.00006563449,0.001302655,0.00006979578,0.0005304597,0.0000276554,0.001709775,0.00002187385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004636383,"about_ca_system_score_gemma":0.0004308417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003428486,"about_ca_topic_score_gemma":0.01103378,"domain_scores_codex":[0.9974323,0.0003540904,0.0005856744,0.0002818348,0.0005022258,0.0008438595],"domain_scores_gemma":[0.9987845,0.0003028844,0.0001607725,0.0002296392,0.0001187282,0.000403439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01032854,0.001473445,0.9401791,0.00007246136,0.0001894942,0.0009748954,0.02733464,0.00240025,0.01530935,0.0004148928,0.0002962773,0.001026645],"study_design_scores_gemma":[0.00964701,0.0005072819,0.9785803,0.0008629339,0.00004990378,0.0003143401,0.00571082,0.001472313,0.00124068,0.0002353515,0.001089536,0.0002895633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748042,0.0001820674,0.001997579,0.01891365,0.0001275996,0.0009279025,0.00001292166,0.00001752656,0.003016582],"genre_scores_gemma":[0.9951251,0.00001956812,0.003420409,0.0004340863,0.0001354726,0.0001916741,0.00001625876,0.00004084211,0.0006166077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03840116,"threshold_uncertainty_score":0.7816536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02511885405954644,"score_gpt":0.2985364298966107,"score_spread":0.2734175758370642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}