{"id":"W2116811274","doi":"10.1093/intimm/dxh098","title":"A chimeric T cell receptor with super-signaling properties","year":2004,"lang":"en","type":"article","venue":"International Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Marsden Fund; Lotto New Zealand; Royal Society; Royal Society Te Apārangi; Wellcome Trust; McGill University","keywords":"T-cell receptor; CD3; Signal transduction; Cell biology; Biology; T cell; Antigen; Molecular biology; Autoimmunity; Chemistry; CD8; Immune system; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00007838132,0.0001867922,0.00018318,0.0001910315,0.0001601871,0.00003013651,0.0002910267,0.0001709824,0.003786119],"category_scores_gemma":[0.00003337955,0.000146144,0.00007698999,0.0001056164,0.0002155068,0.0002561347,0.0000654574,0.0003842007,0.004484523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001544522,"about_ca_system_score_gemma":0.00008519141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002824893,"about_ca_topic_score_gemma":0.00001102819,"domain_scores_codex":[0.9990426,0.00007037554,0.0002781572,0.0002843741,0.00004954842,0.0002749989],"domain_scores_gemma":[0.9994548,0.00002875639,0.0001214719,0.000194985,0.0001884848,0.00001150114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005838196,0.0002231668,0.0002189138,0.000003838028,0.0003100478,0.000003857752,0.0004991798,0.0001426181,0.9945089,0.001715769,0.001038034,0.0007518246],"study_design_scores_gemma":[0.002088732,0.0003511395,0.0004799986,0.00004529682,0.00001743049,0.0002675343,0.0006609191,0.000001699747,0.769584,0.00004794222,0.2262687,0.0001866445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706265,0.002482652,0.001047412,0.001702481,0.008730412,0.0002064778,0.00000469805,0.000200051,0.01499926],"genre_scores_gemma":[0.980074,0.0001176358,0.0002589531,0.0004257682,0.00006654602,0.00004963124,0.0001616806,0.00002459604,0.01882121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2252307,"threshold_uncertainty_score":0.9971246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054180095819255,"score_gpt":0.1996783606594822,"score_spread":0.1891365597012896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}