{"id":"W2116834921","doi":"10.1093/infdis/jis342","title":"Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study)","year":2012,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; School of Medicine, Emory University; School of Medicine, New York University; National Institutes of Health; Universidade de São Paulo; Université de Montréal; University of Washington; Women's College Hospital; University of Illinois at Urbana-Champaign; Universidade Federal do Rio de Janeiro; Department of Science and Technology, Ministry of Science and Technology, India; University of Toronto; Brigham and Women's Hospital; Emory University; University of Rochester; Saint Louis University; University of Ottawa; University of New South Wales; York University; Weill Cornell Medical College; University of Pennsylvania","keywords":"Medicine; Vaccination; Hazard ratio; Placebo; Interim analysis; Confidence interval; Immunology; Vaccine trial; Relative risk; Randomized controlled trial; Internal medicine; Proportional hazards model; Viral load; Virology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01205986,0.0006501981,0.001365943,0.0002683193,0.0002566024,0.0006065507,0.0005814864,0.001066909,0.002267551],"category_scores_gemma":[0.01394312,0.000448043,0.001314885,0.0002970811,0.0005634997,0.0007035875,0.0004795636,0.001179091,0.0002152259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002297322,"about_ca_system_score_gemma":0.0006041454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000309433,"about_ca_topic_score_gemma":0.0004383819,"domain_scores_codex":[0.9951604,0.003444105,0.0002472119,0.0005556956,0.0002975429,0.0002950424],"domain_scores_gemma":[0.9901273,0.00467589,0.002705679,0.001439872,0.0003485178,0.0007027528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8457373,0.005874287,0.09900715,0.0008864183,0.004822615,0.0001862954,0.000415383,0.0007078981,0.005042519,0.0001593078,0.0004764248,0.03668443],"study_design_scores_gemma":[0.1699931,0.4257543,0.3855476,0.0002057496,0.007183162,0.0004350245,0.0001814405,0.004090087,0.00445004,0.0005553425,0.00149989,0.0001042244],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986221,0.0006015555,0.000313901,0.00004537154,0.00003175819,0.0001507414,0.00008105904,0.00001174073,0.0001418129],"genre_scores_gemma":[0.9988647,0.000167795,0.0003705857,0.00006615068,0.0000320562,0.000182137,0.0001114296,0.000003093522,0.0002021348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01205986,"threshold_uncertainty_score":0.06377941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00757180042936727,"score_gpt":0.2813562625690439,"score_spread":0.2737844621396767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}