{"id":"W2116834921","doi":"10.1093/infdis/jis342","title":"Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study)","year":2012,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; School of Medicine, Emory University; School of Medicine, New York University; National Institutes of Health; Universidade de São Paulo; Université de Montréal; University of Washington; Women's College Hospital; University of Illinois at Urbana-Champaign; Universidade Federal do Rio de Janeiro; Department of Science and Technology, Ministry of Science and Technology, India; University of Toronto; Brigham and Women's Hospital; Emory University; University of Rochester; Saint Louis University; University of Ottawa; University of New South Wales; York University; Weill Cornell Medical College; University of Pennsylvania","keywords":"Medicine; Vaccination; Hazard ratio; Placebo; Interim analysis; Confidence interval; Immunology; Vaccine trial; Relative risk; Randomized controlled trial; Internal medicine; Proportional hazards model; Viral load; Virology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003129884,0.0002163492,0.0008517017,0.0001763318,0.00007944038,0.00001953012,0.0001718993,0.00008756824,0.0000522761],"category_scores_gemma":[0.000996319,0.0001372101,0.0002722612,0.0001777842,0.00009838819,0.00003365321,0.00007122302,0.0001933987,0.000001854199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002609827,"about_ca_system_score_gemma":0.00008687054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009514422,"about_ca_topic_score_gemma":0.00007323266,"domain_scores_codex":[0.9962031,0.002201259,0.0008141015,0.000146838,0.0002967762,0.0003379477],"domain_scores_gemma":[0.9978938,0.0005847255,0.000890478,0.0002614573,0.0002083217,0.0001612511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.597033,0.0008632853,0.2366925,0.00002630398,0.0007357453,0.000002968452,0.0002976563,0.00007387394,0.1632767,5.398758e-7,0.00004558108,0.000951899],"study_design_scores_gemma":[0.5766827,0.0148597,0.2094251,0.00013653,0.001116808,0.0000124701,0.0001519668,0.0001709806,0.1971719,0.00008189281,9.363664e-7,0.0001889858],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961374,0.002388041,0.0001093417,0.000009546357,0.0001857132,0.001132622,0.00001513441,0.000005716435,0.00001646784],"genre_scores_gemma":[0.9990611,0.0006903313,0.000004848752,0.000007954613,0.0001403072,0.00003522707,0.000005493815,0.00002461211,0.00003013607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03389521,"threshold_uncertainty_score":0.5595266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00757180042936727,"score_gpt":0.2813562625690439,"score_spread":0.2737844621396767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}