{"id":"W2116860515","doi":"10.1182/blood-2007-12-130096","title":"NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Cancer Institute","keywords":"Biology; Extracellular; Mutant; Mutation; Signal transduction; Exon; Cell biology; Receptor; Genetics; Gene duplication; Gene; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005997253,0.0000954284,0.00008466189,0.00005655596,0.00004678906,0.000004997748,0.00007432533,0.0001457753,0.00002587458],"category_scores_gemma":[0.00002653088,0.0001055827,0.00005145276,0.0001145623,0.00004237514,0.000003621376,0.00002709139,0.00006874112,0.00002452079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001108661,"about_ca_system_score_gemma":0.00006845135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002892316,"about_ca_topic_score_gemma":0.0000642322,"domain_scores_codex":[0.9992965,0.00002997832,0.0001706229,0.0002403808,0.0001015012,0.0001610316],"domain_scores_gemma":[0.9996329,0.00000598072,0.00004545063,0.0002364322,0.00003395954,0.00004528489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001888494,0.0001760693,0.001913299,0.000006434598,0.00002098281,0.00001767742,0.0001144843,0.001203051,0.9953424,0.00001239711,0.0002341335,0.0009401271],"study_design_scores_gemma":[0.002232296,0.0001301556,0.02197632,0.00001649904,0.00003562878,0.0001477212,0.00003165893,0.0003004597,0.9620273,0.00004402174,0.01283698,0.0002209736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966145,0.002142204,0.0003809572,0.0001158262,0.00009085379,0.0001457044,0.000005262701,0.00001578252,0.0004888778],"genre_scores_gemma":[0.9976742,0.0003150928,0.0005743804,0.00004181346,0.0001553422,0.00002016637,0.0002157519,0.00001861055,0.0009846969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03331517,"threshold_uncertainty_score":0.4305536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426821679231553,"score_gpt":0.2382264052336143,"score_spread":0.2239581884412988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}