{"id":"W2116874132","doi":"10.1128/aac.05161-11","title":"Inhibition of HIV-1 by Octadecyloxyethyl Esters of (<i>S</i>)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl] Nucleosides and Evaluation of Their Mechanism of Action","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Cytosine; Cidofovir; Guanine; Nucleic acid; Biology; Reverse transcriptase; Uracil; DNA; Stereochemistry; Mechanism of action; Thymine; Virology; Chemistry; Virus; Biochemistry; Nucleotide; In vitro; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469299,0.0003025142,0.0001657827,0.0001134057,0.00009452831,0.0001878555,0.0002177659,0.0001982727,0.0007618396],"category_scores_gemma":[0.0001449533,0.0001403599,0.0002182883,0.0001119145,0.0001397602,0.0001815444,0.000121649,0.0004172919,0.0002202589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001636439,"about_ca_system_score_gemma":0.0001875508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004348638,"about_ca_topic_score_gemma":0.0006407996,"domain_scores_codex":[0.9998984,0.00001855718,0.00001362037,0.00001770158,0.000025208,0.00002654317],"domain_scores_gemma":[0.9999123,0.00002512445,0.00002382424,0.000008786265,0.00001016205,0.00001984409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001625213,0.00008045782,0.0001056801,0.00004694853,0.000004736256,0.00004415419,0.00001604756,0.000320809,0.9956814,0.00009839179,0.00001517226,0.003423768],"study_design_scores_gemma":[0.00001379085,0.000402282,0.0002398212,0.000002901723,0.000005274127,0.00004714251,0.000004483527,0.0002978078,0.9982242,0.000009435788,0.0007507787,0.000002140936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99347,0.002535118,0.001624464,0.00003976974,0.00002851011,0.00005730356,0.0001748856,0.00001857665,0.002051436],"genre_scores_gemma":[0.986166,0.003817218,0.006288342,0.00006550918,0.00001834345,0.00005560366,0.0005179335,0.00001877256,0.003052308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007618396,"threshold_uncertainty_score":0.002548575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03869346990183048,"score_gpt":0.2712042003562458,"score_spread":0.2325107304544153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}