{"id":"W2116956799","doi":"10.1016/s0140-6736(08)60725-4","title":"Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)","year":2008,"lang":"en","type":"article","venue":"The Lancet","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1865,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Western University","funders":"","keywords":"Ustekinumab; Medicine; Psoriasis; Psoriasis Area and Severity Index; Placebo; Clinical endpoint; Internal medicine; Randomization; Randomized controlled trial; Intention-to-treat analysis; Gastroenterology; Dermatology; Tumor necrosis factor alpha; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002839203,0.001979033,0.004402723,0.0005997928,0.0006470726,0.001246563,0.001041706,0.003262415,0.006709111],"category_scores_gemma":[0.002698109,0.001098738,0.002642589,0.0005586148,0.001654836,0.001632065,0.0005130644,0.003900684,0.001239037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000833668,"about_ca_system_score_gemma":0.0007680503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001266077,"about_ca_topic_score_gemma":0.00159356,"domain_scores_codex":[0.9989111,0.0005333633,0.00008320464,0.0002071855,0.00009297351,0.0001720555],"domain_scores_gemma":[0.9986932,0.0004294012,0.0003181834,0.0001159906,0.00006762917,0.0003756027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9878683,0.001851612,0.0002950405,0.0004130815,0.0005249092,0.00002075694,0.00002715754,0.0001187997,0.001815604,0.0000256896,0.0003174504,0.006721671],"study_design_scores_gemma":[0.9703646,0.02691396,0.001573929,0.00002273993,0.0004726173,0.00002000128,0.000009550867,0.00008897374,0.0002846994,0.00003935529,0.0001978024,0.00001177623],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788167,0.01346628,0.000721868,0.0009886941,0.0005829664,0.001619862,0.001491337,0.0001626246,0.002149645],"genre_scores_gemma":[0.9846485,0.00598669,0.00120023,0.001294888,0.0007202464,0.001418527,0.001375398,0.0000423534,0.003313242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006709111,"threshold_uncertainty_score":0.02244419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512843593995436,"score_gpt":0.2649349371817737,"score_spread":0.2298065012418194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}