{"id":"W2116967011","doi":"10.1097/01.moh.0000160737.52349.aa","title":"Hox regulation of normal and leukemic hematopoietic stem cells","year":2005,"lang":"en","type":"review","venue":"Current Opinion in Hematology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Genome Canada; Terry Fox Research Institute; BC Cancer Agency; Terry Fox Foundation","funders":"","keywords":"Hox gene; Biology; Haematopoiesis; Leukemia; Stem cell; Homeobox; Progenitor cell; Transplantation; Cancer research; Cell biology; Genetics; Gene; Transcription factor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001986664,0.0003072042,0.0008905742,0.0001925459,0.00003304689,0.000005006861,0.0001639727,0.0006202317,0.00001851925],"category_scores_gemma":[0.00000904539,0.0002860154,0.0001480951,0.0001391647,0.0001622556,0.000005090566,0.0001694391,0.0001782082,0.00001645844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003552869,"about_ca_system_score_gemma":0.0001774805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.854065e-7,"about_ca_topic_score_gemma":0.000002202287,"domain_scores_codex":[0.9982151,0.0001914012,0.0007913199,0.000483677,0.00007977302,0.0002387709],"domain_scores_gemma":[0.9991627,0.00004055588,0.0004342233,0.0002751068,0.00003547303,0.00005194352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002383011,0.00008015742,0.0003489009,0.01353494,0.00005638775,2.946926e-7,0.00004615675,0.000005262415,0.000305623,0.0009253318,0.0008571545,0.983816],"study_design_scores_gemma":[0.0003763536,0.00007408675,0.0001510468,0.003759838,0.00004677174,0.0002535479,0.00001464035,0.00001086959,0.001624464,0.0000493393,0.9932937,0.0003453486],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001443442,0.9963991,0.0001007439,0.00001130929,0.001527411,0.0004456913,0.00002261099,0.00000767961,0.0000420017],"genre_scores_gemma":[0.002699355,0.9961692,0.0001142936,0.000003175923,0.0001747062,0.00006679091,0.0006703032,0.00002292202,0.00007921845],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9924365,"threshold_uncertainty_score":0.9999592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04546028020521622,"score_gpt":0.3390306774841594,"score_spread":0.2935703972789432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}