{"id":"W2117011155","doi":"10.1172/jci29383","title":"Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":671,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Texas Southwestern Medical Center","keywords":"PCSK9; Kexin; LDL receptor; Proprotein convertase; Endocytosis; Biology; Receptor; Cell biology; Endocytic cycle; Internal medicine; Endocrinology; Molecular biology; Cholesterol; Lipoprotein; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04176156610301236,"score_gpt":0.3457845208565684,"score_spread":0.304022954753556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}