{"id":"W2117053752","doi":"10.2215/cjn.03791106","title":"Therapeutic Monitoring of Calcineurin Inhibitors for the Nephrologist","year":2007,"lang":"en","type":"review","venue":"Clinical Journal of the American Society of Nephrology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Regional Health Centre; Toronto General Hospital; McGill University Health Centre; Royal Victoria Hospital; University Health Network","funders":"","keywords":"Medicine; Calcineurin; Dosing; Immunosuppression; Pharmacokinetics; Tacrolimus; Therapeutic drug monitoring; Pharmacology; Intensive care medicine; Nephrology; Renal function; Clinical significance; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001419908,0.0002860526,0.003025377,0.0000587745,0.00007533088,0.000004346945,0.0005543236,0.0002549546,0.000005695711],"category_scores_gemma":[0.0001031468,0.0001255135,0.005345319,0.0003551556,0.001950365,0.00002199925,0.00005884232,0.0009348763,9.871387e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000567201,"about_ca_system_score_gemma":0.0003738515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002199302,"about_ca_topic_score_gemma":7.768968e-7,"domain_scores_codex":[0.9965112,0.0003431353,0.002342864,0.000190506,0.000345098,0.0002671808],"domain_scores_gemma":[0.9882415,0.006219563,0.004709752,0.0004360886,0.0002883654,0.0001047241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000877766,0.000435839,0.01380094,0.003638813,0.007316056,0.00001254557,0.00008905998,0.000006724452,0.00003287106,0.00001731544,0.00201752,0.9717546],"study_design_scores_gemma":[0.002157086,0.003287433,0.02564778,0.003837846,0.009728675,0.000527515,0.00019715,0.000005128531,0.0000207142,0.00005321767,0.9544104,0.0001270645],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006606769,0.9885626,0.0006978055,0.002359781,0.0008907917,0.0008336172,0.00003133875,0.000005829819,0.00001147209],"genre_scores_gemma":[0.002889565,0.989675,0.002607384,0.003705666,0.001007509,0.000008359607,0.000002605116,0.00003568177,0.00006819814],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9716275,"threshold_uncertainty_score":0.7186202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2261579294714175,"score_gpt":0.4994815104324336,"score_spread":0.2733235809610161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}