{"id":"W2117059945","doi":"10.1093/humrep/dei120","title":"Simvastatin has deleterious effects on human first trimester placental explants","year":2005,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children; Tel Aviv University","keywords":"Simvastatin; Trophoblast; Cytotrophoblast; Matrigel; Endocrinology; Internal medicine; Placenta; Andrology; HMG-CoA reductase; Reductase; Biology; Pregnancy; Medicine; Fetus; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002025213,0.0002052925,0.0002815826,0.0001099983,0.0005782477,0.00003163481,0.00006029129,0.00007315062,0.00008335635],"category_scores_gemma":[0.00006939494,0.0001818225,0.00009122534,0.00007739207,0.00008356584,0.0001021888,0.00003806708,0.000213186,0.0001804194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000106689,"about_ca_system_score_gemma":0.00001477994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002512046,"about_ca_topic_score_gemma":0.00007280448,"domain_scores_codex":[0.9985865,0.00006124663,0.0002603348,0.0006003954,0.0002292991,0.0002622024],"domain_scores_gemma":[0.9991878,0.00004091353,0.00009661184,0.0005710629,0.00003374329,0.00006990404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00389388,0.003964635,0.08009282,0.003015622,0.001091909,0.0006708079,0.03031973,0.000222334,0.2898979,0.001116008,0.2138157,0.3718987],"study_design_scores_gemma":[0.008910076,0.003892366,0.3813863,0.002095691,0.0003174222,0.0006657937,0.0002945738,0.0000241468,0.4495675,0.0004142687,0.1515926,0.0008392542],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910313,0.0007353424,0.00001378095,0.001902624,0.0003412291,0.0006179123,0.000002877403,0.0002085302,0.005146388],"genre_scores_gemma":[0.9935139,0.00003307316,0.0001706331,0.0003266722,0.001761965,0.00007183894,0.00005945484,0.00002946323,0.004032979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3710594,"threshold_uncertainty_score":0.7414505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06423955161085487,"score_gpt":0.3163642305745319,"score_spread":0.2521246789636771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}