{"id":"W2117083188","doi":"10.1016/j.cell.2015.09.056","title":"Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Irish Research Council; Michigan Technology Tri-Corridor; Higher Education Authority; KU Leuven; Enterprise Ireland; Michigan Economic Development Corporation; National Institutes of Health; Science Foundation Ireland; U.S. Public Health Service; University of Michigan; U.S. Department of Energy","keywords":"Biology; Lectin; Histidine; Effector; Biochemistry; Threonine; Amino acid; Glycan; Cell biology; Glycoprotein; Phosphorylation; Serine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001198511,0.00008969384,0.00007747313,0.00002010745,0.00003199423,0.00002701434,0.0001038735,0.00009559116,0.00001887732],"category_scores_gemma":[0.00004059152,0.00009234379,0.00004468629,0.00006933785,0.00001639507,0.000003710171,0.00006185889,0.000109,0.0000505168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001929498,"about_ca_system_score_gemma":0.00005802418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001677676,"about_ca_topic_score_gemma":0.00001935361,"domain_scores_codex":[0.9993679,0.00002871899,0.00006814483,0.0002210559,0.000129682,0.0001844858],"domain_scores_gemma":[0.9996629,0.00001046956,0.00002431406,0.0001697523,0.00004635549,0.00008625331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005521492,0.0000486324,0.001105736,0.000003772606,0.00001315223,0.00000124847,0.00001885753,0.0001297749,0.9951631,4.342067e-7,0.001354428,0.002105658],"study_design_scores_gemma":[0.0004521846,0.00007732744,0.0005448959,0.000002126581,0.000004031193,5.50257e-7,0.00001340711,0.004533177,0.9595169,0.00001170606,0.03473125,0.0001124221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886923,0.0006293794,0.009398419,0.00005287888,0.00012077,0.0001060353,0.000008736236,0.00001654737,0.0009748943],"genre_scores_gemma":[0.9981924,0.00001952672,0.0002501115,0.00005081794,0.0001270368,0.000008365107,0.00005337871,0.00001591916,0.001282404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03564617,"threshold_uncertainty_score":0.3765671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949154673487473,"score_gpt":0.25723170531224,"score_spread":0.2377401585773652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}