{"id":"W2117083188","doi":"10.1016/j.cell.2015.09.056","title":"Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Irish Research Council; Michigan Technology Tri-Corridor; Higher Education Authority; KU Leuven; Enterprise Ireland; Michigan Economic Development Corporation; National Institutes of Health; Science Foundation Ireland; U.S. Public Health Service; University of Michigan; U.S. Department of Energy","keywords":"Biology; Lectin; Histidine; Effector; Biochemistry; Threonine; Amino acid; Glycan; Cell biology; Glycoprotein; Phosphorylation; Serine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484899,0.0004259471,0.0002147487,0.0002502803,0.0001630558,0.0004404116,0.0002917859,0.0003625111,0.0009466462],"category_scores_gemma":[0.0001152298,0.0001251512,0.0002553765,0.0001920747,0.0002634271,0.0002836423,0.0002906578,0.000784906,0.0003855356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005216621,"about_ca_system_score_gemma":0.0003664792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004927405,"about_ca_topic_score_gemma":0.0008083709,"domain_scores_codex":[0.999894,0.00002289468,0.000007672753,0.00001321255,0.00002719719,0.00003501499],"domain_scores_gemma":[0.9999257,0.00001353443,0.00001941849,0.000009564929,0.00000902953,0.00002266007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004269105,0.00002351951,0.00003835961,0.00001048912,0.000002109018,0.00002553606,0.000005111981,0.0001173764,0.9981652,0.0005512394,0.00002682078,0.0009914958],"study_design_scores_gemma":[0.00001159129,0.0001326653,0.0002490513,0.000002239364,0.00001054571,0.0001434023,0.000009899252,0.0008655693,0.9948302,0.0001695995,0.003571698,0.000003468581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643223,0.0008004234,0.02877115,0.00039251,0.0001083212,0.0001096554,0.0003182037,0.0002754289,0.00490207],"genre_scores_gemma":[0.9774812,0.0005242905,0.01734308,0.0001234813,0.0000225344,0.00004544643,0.0002529572,0.00005479763,0.004152193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009466462,"threshold_uncertainty_score":0.003784955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949154673487473,"score_gpt":0.25723170531224,"score_spread":0.2377401585773652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}