{"id":"W2117124166","doi":"10.1128/jvi.02723-07","title":"Vaccinia Virus DNA Ligase Recruits Cellular Topoisomerase II to Sites of Viral Replication and Assembly","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Research Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Biology; Topoisomerase; DNA ligase; Molecular biology; Vaccinia; Virology; Viral replication; Immunoelectron microscopy; Virus; Recombinant DNA; DNA; Biochemistry; Gene; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002480208,0.00009590617,0.0002114716,0.00008000929,0.00006276889,0.000003673436,0.0001256493,0.0001354483,0.00001696469],"category_scores_gemma":[0.00005555775,0.00008733531,0.00007654685,0.00005334834,0.00003263254,0.000005160285,0.00007705313,0.0000938525,0.000001346381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001029336,"about_ca_system_score_gemma":0.00006114528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001081956,"about_ca_topic_score_gemma":0.00001415129,"domain_scores_codex":[0.9992146,0.00004706226,0.0003311779,0.0001766065,0.00009576479,0.0001347475],"domain_scores_gemma":[0.9992208,0.00001103643,0.0002687856,0.0002573218,0.0001385962,0.0001034395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004643557,0.00008367794,0.0002210301,0.000005099449,0.00005175775,0.0000151168,0.0001553261,0.00001241388,0.9960966,0.00007748594,0.0004120953,0.002405096],"study_design_scores_gemma":[0.0006029233,0.003381088,0.001903964,0.000004757993,0.00003099678,0.0002569141,0.00001357118,0.00001393338,0.9723649,0.0001802471,0.02116355,0.00008316193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970478,0.001152018,0.0008752838,0.0006451638,0.0001196817,0.0000882408,0.000008107079,0.000001925584,0.00006176017],"genre_scores_gemma":[0.9967893,0.001234702,0.0006783332,0.0009415415,0.0002238493,0.000003377371,0.000006596398,0.00001062149,0.0001116712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02373166,"threshold_uncertainty_score":0.3561431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02216264833663863,"score_gpt":0.2758190472706739,"score_spread":0.2536563989340353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}