{"id":"W2117124166","doi":"10.1128/jvi.02723-07","title":"Vaccinia Virus DNA Ligase Recruits Cellular Topoisomerase II to Sites of Viral Replication and Assembly","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Research Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Biology; Topoisomerase; DNA ligase; Molecular biology; Vaccinia; Virology; Viral replication; Immunoelectron microscopy; Virus; Recombinant DNA; DNA; Biochemistry; Gene; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303888,0.0002548696,0.0003142402,0.0002141882,0.0002087612,0.0005362406,0.0001524828,0.0002017347,0.0007793623],"category_scores_gemma":[0.0001533752,0.0002524682,0.0002774622,0.0001212989,0.0001542842,0.0001884856,0.0002399368,0.0003709325,0.000566635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005716346,"about_ca_system_score_gemma":0.0002196491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009791725,"about_ca_topic_score_gemma":0.00149849,"domain_scores_codex":[0.9998547,0.00001896208,0.00001204211,0.00004465106,0.00003844356,0.00003114472],"domain_scores_gemma":[0.9999307,0.00001011556,0.00001611939,0.000009991502,0.00001151929,0.00002152814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002674324,0.000005130796,0.0004371235,0.00001689277,0.000002621377,0.00002153104,0.000008396841,0.00001611025,0.9988882,0.00005230592,0.00001194941,0.0005129272],"study_design_scores_gemma":[0.00001207533,0.000108281,0.01310469,0.000005931201,0.000008371691,0.0002073697,0.0000285118,0.0009424353,0.9817515,0.0000553196,0.003771959,0.000003553564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937717,0.001371528,0.003306919,0.00004619246,0.00001920852,0.00001670096,0.0001718005,0.00005098145,0.001244894],"genre_scores_gemma":[0.991799,0.0007060497,0.003725575,0.0000307174,0.000008387522,0.00002212753,0.0006541395,0.00001957826,0.003034444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009791725,"threshold_uncertainty_score":0.00414753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02216264833663863,"score_gpt":0.2758190472706739,"score_spread":0.2536563989340353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}