{"id":"W2117195973","doi":"10.1124/dmd.104.002360","title":"EFFECT OF EARLY PHASE ADJUVANT ARTHRITIS ON HEPATIC P450 ENZYMES AND PHARMACOKINETICS OF VERAPAMIL: AN ALTERNATIVE APPROACH TO THE USE OF AN ANIMAL MODEL OF INFLAMMATION FOR PHARMACOKINETIC STUDIES","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Pharmacokinetics; Pharmacology; Verapamil; Arthritis; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001085092,0.0003253368,0.0007815115,0.0002562182,0.0001207354,0.00001499003,0.0002008384,0.0000969204,0.000006512653],"category_scores_gemma":[0.00006845308,0.0002511154,0.0001174286,0.0001933683,0.0003317641,0.0003835562,0.00007562968,0.0002024339,3.489272e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001021633,"about_ca_system_score_gemma":0.00002765008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002960767,"about_ca_topic_score_gemma":0.000004928801,"domain_scores_codex":[0.9975703,0.0007262834,0.0007760546,0.0003656282,0.0002928385,0.0002688622],"domain_scores_gemma":[0.9982336,0.0005033128,0.0005064317,0.0002151445,0.0003407302,0.0002008506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006658891,0.0009862444,0.0001123171,0.0004372126,0.000358239,6.087741e-7,0.008252409,0.05883222,0.7060385,0.00201314,0.00006228259,0.2162479],"study_design_scores_gemma":[0.006175783,0.000968615,0.0007299309,0.00004025819,0.0009536795,0.000002368176,0.00008264271,0.3296771,0.6604747,0.0001233485,0.0006091878,0.0001624495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874861,0.008388075,0.0009723437,0.0001078473,0.0001994906,0.001547846,0.001255909,0.00001493181,0.00002741831],"genre_scores_gemma":[0.9917694,0.005696405,0.001744087,0.0002114437,0.0002805305,0.0001665377,0.00009004543,0.00003061557,0.00001097467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2708448,"threshold_uncertainty_score":0.9999941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1002131909567073,"score_gpt":0.4201155414036279,"score_spread":0.3199023504469206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}