{"id":"W2117195973","doi":"10.1124/dmd.104.002360","title":"EFFECT OF EARLY PHASE ADJUVANT ARTHRITIS ON HEPATIC P450 ENZYMES AND PHARMACOKINETICS OF VERAPAMIL: AN ALTERNATIVE APPROACH TO THE USE OF AN ANIMAL MODEL OF INFLAMMATION FOR PHARMACOKINETIC STUDIES","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Pharmacokinetics; Pharmacology; Verapamil; Arthritis; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006118413,0.0008192628,0.001045889,0.0005474764,0.0002631375,0.0007889313,0.0004495172,0.0007658055,0.001796342],"category_scores_gemma":[0.001071344,0.0003746213,0.0005663122,0.0004768776,0.001051525,0.001069688,0.0002236489,0.002860697,0.0003919799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006145592,"about_ca_system_score_gemma":0.0008605439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140526,"about_ca_topic_score_gemma":0.002947366,"domain_scores_codex":[0.9994344,0.0001650667,0.00004735025,0.0000702935,0.00008945117,0.0001934605],"domain_scores_gemma":[0.9985433,0.0005772162,0.0002509312,0.0002587974,0.00009493878,0.0002747768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05697428,0.003745614,0.0006955645,0.00008307349,0.00004998326,0.0002172468,0.000103733,0.0006086106,0.9276565,0.000298568,0.0001756706,0.009391133],"study_design_scores_gemma":[0.001256528,0.04129788,0.003195863,0.000009436556,0.0001295555,0.0001507193,0.00006118316,0.002224223,0.950499,0.0001997213,0.0009421908,0.00003385367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961067,0.0009201749,0.001479606,0.000216971,0.0001686419,0.00006635841,0.0003022682,0.00008042588,0.0006588959],"genre_scores_gemma":[0.9936064,0.0007158353,0.001752559,0.00009638981,0.0001045882,0.00009976816,0.0003785292,0.00003510598,0.003210701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001796342,"threshold_uncertainty_score":0.00600934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1002131909567073,"score_gpt":0.4201155414036279,"score_spread":0.3199023504469206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}