{"id":"W2117206782","doi":"10.1053/j.seminoncol.2007.07.010","title":"Clinically Relevant Biology of Hereditary Breast Cancer","year":2007,"lang":"en","type":"review","venue":"Seminars in Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Breast cancer; BRCA2 Protein; Identification (biology); Gene; Epidemiology; Cancer; Genetics; Mutation; Bioinformatics; Computational biology; Pathology; Biology; Germline mutation; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007131008,0.001278381,0.001609751,0.001979555,0.0003037288,0.00112296,0.001470417,0.001828675,0.00226368],"category_scores_gemma":[0.0008848828,0.0003552323,0.0003622499,0.001959282,0.001248335,0.001277795,0.0007610825,0.00235619,0.001682648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0012829,"about_ca_system_score_gemma":0.0010424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008418157,"about_ca_topic_score_gemma":0.00154206,"domain_scores_codex":[0.9998062,0.00004532503,0.00002232107,0.00003251273,0.00007158264,0.00002208856],"domain_scores_gemma":[0.9996798,0.0001850528,0.00002591079,0.00001353908,0.00006741039,0.00002826322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009602713,0.00007296656,0.0004291025,0.008475424,0.00006832006,0.001246955,0.00007359834,0.0007337278,0.002644401,0.0116225,0.1139299,0.860607],"study_design_scores_gemma":[0.00002618429,0.00004098403,0.0009075569,0.001712873,0.00006807842,0.006227015,0.00005988804,0.0001225835,0.0005275141,0.005795055,0.9844939,0.00001836974],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007320951,0.9977949,0.0002172538,0.0004779962,0.0004909988,0.00000280626,0.000008188203,0.000007553656,0.0009271196],"genre_scores_gemma":[0.0007874912,0.996932,0.0002636825,0.00044155,0.0008294379,0.000006439288,0.00002226234,0.000001531269,0.00071563],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00226368,"threshold_uncertainty_score":0.009308159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04336574340209221,"score_gpt":0.4329801532678643,"score_spread":0.3896144098657721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}