{"id":"W2117232596","doi":"10.1002/syn.20193","title":"Antiparkinson concentrations of pramipexole and PHNO occupy dopamine D2high and D3high receptors","year":2005,"lang":"en","type":"article","venue":"Synapse","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Pramipexole; Apomorphine; Dopamine receptor D3; Dopamine receptor D2; Dopamine receptor; Chemistry; Bromocriptine; Dopamine; Spiperone; Pharmacology; Receptor; Dopaminergic; Domperidone; Dopamine agonist; Endocrinology; Internal medicine; Parkinson's disease; Medicine; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317497,0.0001848581,0.0002224876,0.00009559665,0.0001373271,0.00004974141,0.0001708395,0.00008620983,0.0002497926],"category_scores_gemma":[0.0002396902,0.0001726702,0.00003588191,0.0002343587,0.0004881914,0.0003889739,0.00005027574,0.000175595,0.00003126378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002006273,"about_ca_system_score_gemma":0.0000446071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002400877,"about_ca_topic_score_gemma":0.00001355149,"domain_scores_codex":[0.998534,0.0001326686,0.0003174549,0.0004686225,0.0002563585,0.000290864],"domain_scores_gemma":[0.9992133,0.0001915751,0.00012599,0.000259101,0.00003729642,0.0001726917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003565782,0.0001333479,0.01223218,0.00002810539,0.00000292858,0.00000898306,0.0005124605,0.000007507357,0.9776872,0.000864386,0.0002817223,0.008205499],"study_design_scores_gemma":[0.0006588442,0.0001601002,0.008820654,0.00003317226,0.00002168873,0.00006050089,0.0000364868,0.00007314817,0.9667496,0.00002866,0.0231532,0.0002039203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974298,0.000130057,0.00003472357,0.001387146,0.0001820972,0.0003649753,0.00004860266,0.00006960031,0.0003530298],"genre_scores_gemma":[0.9982232,0.0002811785,0.000517778,0.000610008,0.00005297378,0.00002235238,0.000002738634,0.00002087997,0.0002688907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02287148,"threshold_uncertainty_score":0.7041288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02231127017247854,"score_gpt":0.2750481848057269,"score_spread":0.2527369146332484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}