{"id":"W2117302579","doi":"10.1189/jlb.0506321","title":"CD4+ T cells stimulate memory CD8+ T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion","year":2006,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"CD80; Cytotoxic T cell; Biology; Antigen-presenting cell; Cell biology; Interleukin 21; IL-2 receptor; Natural killer T cell; T cell; Streptamer; CD40; CD8; Secretion; Antigen; Immune system; In vitro; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004384249,0.0003702164,0.0007817441,0.0003181647,0.0002591655,0.00002224089,0.0002513361,0.0006863782,0.0001755247],"category_scores_gemma":[0.00002240431,0.0003029139,0.0001480533,0.0001032147,0.0008429041,0.0001480879,0.000178262,0.0004627667,0.00006909248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007681621,"about_ca_system_score_gemma":0.00009639355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001905318,"about_ca_topic_score_gemma":0.00002119202,"domain_scores_codex":[0.9976037,0.0005442151,0.0008758938,0.0003952766,0.00005260414,0.0005283376],"domain_scores_gemma":[0.9984641,0.0003215151,0.0007106326,0.0002475612,0.0001897478,0.0000664218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006177625,0.0001772804,0.001433117,0.00003372722,0.0001172808,0.00005231367,0.0001138592,0.0001221172,0.9931933,0.0001120655,0.001550891,0.002476296],"study_design_scores_gemma":[0.005598338,0.001398543,0.003853489,0.00004648824,0.0001640698,0.001177939,0.0001319122,0.0001353768,0.9656797,0.0009496166,0.02046549,0.0003990577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735278,0.02333176,0.001271344,0.0001452368,0.001207471,0.0001996907,0.00002625247,0.00003882873,0.0002515634],"genre_scores_gemma":[0.997176,0.001142721,0.0004233771,0.0002371317,0.0001549414,0.000002736375,0.00008065076,0.00003034615,0.000752078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02751361,"threshold_uncertainty_score":0.9999423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009464441576049224,"score_gpt":0.2196986390661592,"score_spread":0.21023419749011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}