{"id":"W2117311687","doi":"10.1124/jpet.106.116640","title":"STI-571 (Imatinib Mesylate) Enhances the Apoptotic Efficacy of Pyrrolo-1,5-Benzoxazepine-6, a Novel Microtubule-Targeting Agent, in Both STI-571-Sensitive and -Resistant Bcr-Abl-Positive Human Chronic Myeloid Leukemia Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"","keywords":"Myeloid leukemia; K562 cells; Imatinib mesylate; Apoptosis; Cancer research; Propidium iodide; Nocodazole; Imatinib; breakpoint cluster region; Chemistry; Pharmacology; Medicine; Cell; Programmed cell death; Internal medicine; Receptor; Biochemistry; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001073628,0.0004106679,0.0008185678,0.000238409,0.0002341609,0.00002308592,0.0001767238,0.0002019488,0.0001068511],"category_scores_gemma":[0.0000179828,0.0003007977,0.0001673014,0.0002096198,0.0006592236,0.0001424623,0.0001106664,0.0007407265,0.000002543329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001837395,"about_ca_system_score_gemma":0.0005149498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009648089,"about_ca_topic_score_gemma":0.00001696856,"domain_scores_codex":[0.9973799,0.0002021947,0.001106874,0.0003378004,0.0003446278,0.0006285787],"domain_scores_gemma":[0.9980891,0.0005803521,0.0008506768,0.000137246,0.0001460154,0.0001966146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00337093,0.0008452681,0.0001902033,0.00009369547,0.001081051,0.0002380699,0.005039642,0.00006873177,0.9881019,0.00003817123,0.0000727079,0.0008596472],"study_design_scores_gemma":[0.01601413,0.002527017,0.01174923,0.0002869444,0.0006390064,0.0003556328,0.002228504,0.0003260789,0.9652125,0.0000139688,0.0004083711,0.000238583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867383,0.01150694,0.0001148147,0.0002620821,0.0004032189,0.0007459976,0.00001917158,0.00001274862,0.0001966894],"genre_scores_gemma":[0.9964035,0.001383473,0.0008420814,0.0008797623,0.0003499473,0.000008021741,0.00001003035,0.00004359002,0.00007962903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02288934,"threshold_uncertainty_score":0.9999444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161437683090129,"score_gpt":0.3376578373802562,"score_spread":0.3160434605493549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}