{"id":"W2117311687","doi":"10.1124/jpet.106.116640","title":"STI-571 (Imatinib Mesylate) Enhances the Apoptotic Efficacy of Pyrrolo-1,5-Benzoxazepine-6, a Novel Microtubule-Targeting Agent, in Both STI-571-Sensitive and -Resistant Bcr-Abl-Positive Human Chronic Myeloid Leukemia Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"","keywords":"Myeloid leukemia; K562 cells; Imatinib mesylate; Apoptosis; Cancer research; Propidium iodide; Nocodazole; Imatinib; breakpoint cluster region; Chemistry; Pharmacology; Medicine; Cell; Programmed cell death; Internal medicine; Receptor; Biochemistry; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143257,0.0003274007,0.0004693569,0.0003089236,0.000215386,0.0002475751,0.0002087608,0.0002745175,0.002122869],"category_scores_gemma":[0.0001265775,0.0001543732,0.0001932946,0.0002965206,0.0001641673,0.0002382135,0.0001563928,0.000701764,0.0004409796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002923512,"about_ca_system_score_gemma":0.0002890002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001271481,"about_ca_topic_score_gemma":0.002568742,"domain_scores_codex":[0.9998943,0.00001914712,0.00001142967,0.0000119587,0.00002968441,0.00003350976],"domain_scores_gemma":[0.999936,0.00001468012,0.00001484367,0.000007680308,0.000006291579,0.00002041701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002092238,0.0004404733,0.0008014821,0.0002542779,0.00004406739,0.0001985444,0.0001119655,0.0007310617,0.9752196,0.000583616,0.001100247,0.01842241],"study_design_scores_gemma":[0.0005259598,0.004468975,0.01590123,0.00002506643,0.00008354639,0.0006116689,0.00008037368,0.002625412,0.9698433,0.00009740531,0.005720083,0.00001697197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947701,0.001564688,0.000258995,0.0001138098,0.0000383616,0.00003395119,0.0004268661,0.00007695406,0.002716253],"genre_scores_gemma":[0.9967394,0.001188798,0.0002881782,0.00002907578,0.00001073536,0.00002218036,0.0005315047,0.00000706035,0.001183057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002122869,"threshold_uncertainty_score":0.007101715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161437683090129,"score_gpt":0.3376578373802562,"score_spread":0.3160434605493549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}