{"id":"W2117347104","doi":"10.1002/cbic.200900172","title":"Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities","year":2009,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Amgen (Canada); Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; Leukemia and Lymphoma Society","keywords":"Salicylic acid; In vitro; Phosphorylation; Chemistry; Computational biology; Biochemistry; Combinatorial chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327202,0.0004032651,0.0002643286,0.0001479355,0.0001547567,0.0002480574,0.0002135633,0.0001809101,0.001455919],"category_scores_gemma":[0.00008223842,0.0001268316,0.0002477938,0.0001657213,0.0001501989,0.0001177731,0.0001686819,0.0004323788,0.0005176858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000232957,"about_ca_system_score_gemma":0.0001757305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005171786,"about_ca_topic_score_gemma":0.001053695,"domain_scores_codex":[0.9999051,0.00001490433,0.000009115666,0.00001514821,0.00002911638,0.00002672246],"domain_scores_gemma":[0.9999501,0.000008131485,0.00001390661,0.000006686417,0.000004374508,0.00001680148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001166499,0.00003285324,0.00005889193,0.00002984793,0.000005314415,0.00003183071,0.00001046122,0.0001824003,0.997391,0.00008894918,0.00004747567,0.002004211],"study_design_scores_gemma":[0.00003926774,0.0003899047,0.0003669075,0.000001913831,0.00001133095,0.00009159282,0.000005958033,0.0003199307,0.9967734,0.00001683186,0.001979951,0.000002986858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895111,0.002129824,0.005113475,0.0001001921,0.00003408887,0.0001029046,0.0006216753,0.0001005757,0.002286187],"genre_scores_gemma":[0.9929454,0.001077673,0.002925364,0.0000366504,0.000009003754,0.00004998206,0.000633838,0.00001613545,0.002305953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455919,"threshold_uncertainty_score":0.004870594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009096563944113826,"score_gpt":0.2236634757991341,"score_spread":0.2145669118550203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}