{"id":"W2117347104","doi":"10.1002/cbic.200900172","title":"Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities","year":2009,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Amgen (Canada); Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; Leukemia and Lymphoma Society","keywords":"Salicylic acid; In vitro; Phosphorylation; Chemistry; Computational biology; Biochemistry; Combinatorial chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006210773,0.000200171,0.0003131741,0.0001526519,0.00003672143,0.00001346389,0.00004973539,0.00006810398,0.0000291108],"category_scores_gemma":[0.0000128881,0.0001740195,0.00009072747,0.0001965816,0.00008818431,0.00008214055,0.000006736025,0.0002368373,0.000001301752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001074462,"about_ca_system_score_gemma":0.0001361565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009230078,"about_ca_topic_score_gemma":0.00001122395,"domain_scores_codex":[0.9990628,0.00001478183,0.0002385003,0.0002868198,0.0001834268,0.0002136898],"domain_scores_gemma":[0.9994943,0.00002782898,0.0001179412,0.0001675864,0.00008323843,0.0001091244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002359037,0.0005408898,0.00009313999,0.00010351,0.00003339059,0.00003052076,0.0008008943,0.00005253381,0.9941314,0.00001262063,0.0000197763,0.001822303],"study_design_scores_gemma":[0.002701422,0.0007496579,0.007331776,0.0002291857,0.00009040386,0.00003197195,0.001165654,0.001032212,0.986407,0.00001478568,0.00007255816,0.0001733142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964912,0.0001922312,0.001176096,0.0003819117,0.0000268229,0.0003181366,0.00005234343,0.00002990409,0.001331381],"genre_scores_gemma":[0.9977403,0.00002173975,0.001590061,0.0003649261,0.00002535224,0.00002285572,0.0001204279,0.00002157691,0.0000927693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007724326,"threshold_uncertainty_score":0.709631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009096563944113826,"score_gpt":0.2236634757991341,"score_spread":0.2145669118550203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}