{"id":"W2117353601","doi":"10.1517/14656566.1.4.623","title":"Replicating herpes simplex virus vectors for cancer gene therapy","year":2000,"lang":"en","type":"review","venue":"Expert Opinion on Pharmacotherapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; World Health Organization","keywords":"Oncolytic virus; Herpes simplex virus; Medicine; Virus; Disease; Genetic enhancement; Cancer; Radiation therapy; Cancer cell; Virology; Chemotherapy; Vector (molecular biology); Cancer research; Immunology; HSL and HSV; Gene; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000434505,0.0009464846,0.00121429,0.0002204211,0.0003001633,0.00008559659,0.001004909,0.0005575857,0.001181439],"category_scores_gemma":[0.00001572877,0.0007878343,0.001015775,0.0002958302,0.000114023,0.000007663082,0.00004945423,0.0003069914,0.00005055145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001384252,"about_ca_system_score_gemma":0.0005673632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005722039,"about_ca_topic_score_gemma":0.00001078556,"domain_scores_codex":[0.9960501,0.000461202,0.0007686603,0.001477442,0.0004103458,0.0008322943],"domain_scores_gemma":[0.9979353,0.0001189514,0.0003883488,0.001189635,0.0001132924,0.00025449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00243935,0.0002523616,1.66066e-7,0.0002392224,0.0006746706,9.991156e-7,0.0000631541,0.00001182803,0.03874311,0.000003014977,0.02191945,0.9356527],"study_design_scores_gemma":[0.001557156,0.001599988,8.324409e-8,0.0004669124,0.000009270372,0.000005066222,0.000003324712,0.00001254712,0.1993337,0.000006742296,0.7963083,0.0006969425],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003168523,0.9949867,0.00006446366,0.0001895957,0.0008086596,0.002876705,0.0005470209,0.00008763104,0.0001224163],"genre_scores_gemma":[0.000009095244,0.9845389,0.0002187029,0.003226458,0.004727997,0.00497021,0.00119632,0.0004472349,0.0006650463],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9349557,"threshold_uncertainty_score":0.9997316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1294799134940627,"score_gpt":0.48552920033053,"score_spread":0.3560492868364673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}