{"id":"W2117383437","doi":"10.3390/v6093487","title":"Fitness Impaired Drug Resistant HIV-1 Is Not Compromised in Cell-to-Cell Transmission or Establishment of and Reactivation from Latency","year":2014,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"National Institutes of Health; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Dolutegravir; Virology; Viral replication; Integrase inhibitor; Drug; Drug resistance; Integrase; Lentivirus; Latency (audio); Cell; Biology; Transmission (telecommunications); Virus latency; Cell culture; Viral load; Virus; Human immunodeficiency virus (HIV); Pharmacology; Viral disease; Genetics; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610102,0.0001261491,0.0002424763,0.0001248038,0.00006704402,0.00001131813,0.0001018607,0.00008961454,0.0004008523],"category_scores_gemma":[0.00002885045,0.00008962226,0.00002880975,0.0001172303,0.00005815695,0.0000810234,0.00003557768,0.0001052945,0.0001327351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003352323,"about_ca_system_score_gemma":0.00005412694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002364501,"about_ca_topic_score_gemma":0.0000982088,"domain_scores_codex":[0.999036,0.0001839893,0.0002478888,0.0002610493,0.00005418403,0.0002168734],"domain_scores_gemma":[0.9993892,0.0002681797,0.00006814877,0.0001959049,0.00003304478,0.00004549434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002908272,0.0004530496,0.005404055,0.00004622108,0.00002519759,0.000004805357,0.001847224,0.000003312345,0.980459,0.000007347241,0.002467724,0.00637381],"study_design_scores_gemma":[0.004131119,0.0003369844,0.04265393,0.00008435245,0.0000164445,4.67654e-7,0.0001716556,0.00001573081,0.9325698,0.00003864044,0.01987364,0.0001072105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980788,0.0004131916,0.00009964429,0.0003816715,0.00003629726,0.000349546,0.0002823359,0.00001965134,0.0003388641],"genre_scores_gemma":[0.9982982,0.0001460315,0.0003293788,0.0001335269,0.000006451718,0.00002885241,0.0001369067,0.00001062549,0.0009100061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04788916,"threshold_uncertainty_score":0.4389051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02298425509583537,"score_gpt":0.262141282186693,"score_spread":0.2391570270908576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}