{"id":"W2117408969","doi":"10.1080/00365520252903152","title":"Cholestatic Effect of Large Bilirubin Loads and Cholestasis Protection Conferred by Cholic Acid Co-infusion: a Molecular and Ultrastructural Study","year":2002,"lang":"en","type":"article","venue":"Scandinavian Journal of Gastroenterology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norges Forskningsråd; McMaster University","keywords":"Cholestasis; Cholic acid; Bile Salt Export Pump; Bilirubin; Hepatocyte; Bile acid; Internal medicine; Chemistry; Taurocholic acid; Transporter; Progressive familial intrahepatic cholestasis; Endocrinology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002495407,0.0003057801,0.0003720197,0.000266742,0.0001645921,0.0002502268,0.0001657975,0.0004316465,0.001377818],"category_scores_gemma":[0.0001268168,0.000218012,0.0004014494,0.0001559737,0.0005294633,0.0003957807,0.0002519637,0.0005392357,0.0003654891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003059731,"about_ca_system_score_gemma":0.0001722707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003491366,"about_ca_topic_score_gemma":0.0003846274,"domain_scores_codex":[0.999842,0.00002353998,0.0000146907,0.00002872504,0.00004084828,0.0000500803],"domain_scores_gemma":[0.9997882,0.00003075313,0.00006012161,0.00002677561,0.000033581,0.0000605809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006592543,0.00003392284,0.0003280455,0.00005260494,0.000007312201,0.0001602052,0.00001962974,0.0000166738,0.9980038,0.00004264708,0.000009664955,0.0006663472],"study_design_scores_gemma":[0.00006113355,0.002073587,0.02837563,0.00001022055,0.00005408601,0.001134677,0.0001227252,0.0005774764,0.9663131,0.00007265876,0.001192933,0.00001182907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938409,0.002265993,0.00229112,0.00007129486,0.00004499414,0.00003486653,0.000159037,0.00006336508,0.001228318],"genre_scores_gemma":[0.9935917,0.001585183,0.002191676,0.00005458209,0.00002258328,0.00004455098,0.0002913974,0.00002203077,0.002196207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377818,"threshold_uncertainty_score":0.004609287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007406941847152765,"score_gpt":0.2532615927331633,"score_spread":0.2458546508860106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}