{"id":"W2117416398","doi":"10.1042/bj20121580","title":"Insight into <i>S</i>-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits","year":2013,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Methionine Adenosyltransferase; Biochemistry; Protein subunit; Transferase; Oxidoreductase; Cofactor; Ligand (biochemistry); Methionine; Methylation; Biology; Binding site; Chemistry; Protein structure; Stereochemistry; Enzyme; Amino acid; DNA; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003195312,0.0002005748,0.0003288295,0.00008787109,0.0003434125,0.00007939189,0.000388343,0.0002052234,0.0004623238],"category_scores_gemma":[0.0004328561,0.00009653113,0.0001691974,0.0002963555,0.0006374806,0.0001098546,0.0001508592,0.000949222,0.000006639711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000579951,"about_ca_system_score_gemma":0.0001462001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005671837,"about_ca_topic_score_gemma":0.00001400363,"domain_scores_codex":[0.9982057,0.0001757,0.000440961,0.0002314827,0.000667307,0.0002789157],"domain_scores_gemma":[0.9985372,0.0003462814,0.0001143863,0.0004531493,0.000276321,0.0002726311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005477685,0.0000685765,0.005302261,0.00003907258,0.000215487,0.00001063231,0.0007292138,3.519869e-7,0.9872547,0.00007053455,0.004673885,0.001580513],"study_design_scores_gemma":[0.0009094753,0.0001231339,0.123529,0.0001861617,0.0002148198,0.0002513176,0.0002472638,0.00001601336,0.8720552,0.001046644,0.0012975,0.0001234412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883344,0.004463468,0.0000131599,0.006670547,0.00007575513,0.0002768263,0.00001541493,0.0000123776,0.0001380874],"genre_scores_gemma":[0.9983987,0.0002814655,0.000326993,0.0004350771,0.0003945337,0.000005148086,0.000014453,0.00002464295,0.0001190465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1182267,"threshold_uncertainty_score":0.5062122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607377912391525,"score_gpt":0.264208707535638,"score_spread":0.2481349284117228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}