{"id":"W2117428432","doi":"10.1158/1535-7163.mct-13-0842","title":"The Tyrphostin NT157 Suppresses Insulin Receptor Substrates and Augments Therapeutic Response of Prostate Cancer","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver General Hospital","funders":"Canadian Institutes of Health Research","keywords":"LNCaP; Prostate cancer; IRS1; Cancer research; Insulin-like growth factor 1 receptor; Downregulation and upregulation; Protein kinase B; PI3K/AKT/mTOR pathway; Androgen receptor; MAPK/ERK pathway; Endocrinology; Insulin receptor; Cancer; Signal transduction; Internal medicine; Biology; Growth factor; Receptor; Medicine; Insulin; Insulin resistance; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007455381,0.0003113535,0.0003116142,0.0001862311,0.00008420664,0.0001753223,0.0001962407,0.0001623698,0.001183016],"category_scores_gemma":[0.00007097425,0.00008715042,0.0001879622,0.0001059221,0.0001165846,0.0001125389,0.00008744802,0.000538443,0.000205773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002309978,"about_ca_system_score_gemma":0.0002732065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000704644,"about_ca_topic_score_gemma":0.001656047,"domain_scores_codex":[0.9999433,0.000007443396,0.000004431754,0.000007084652,0.00002571286,0.00001199728],"domain_scores_gemma":[0.999954,0.00000565702,0.00001310894,0.000004051296,0.000006580507,0.00001661058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004494644,0.0004131663,0.0002665521,0.0000524461,0.0000126311,0.00006026754,0.00001284883,0.0002955051,0.9911747,0.00008254771,0.0001482066,0.007031584],"study_design_scores_gemma":[0.0001453128,0.006729133,0.007638834,0.00001070879,0.0000381036,0.0004597339,0.00002961783,0.002191049,0.9786417,0.00003553306,0.004071607,0.000008567518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967241,0.000950405,0.000555766,0.00005791946,0.00003057405,0.00003583975,0.000138843,0.00005932737,0.001447383],"genre_scores_gemma":[0.996712,0.0007078109,0.0005147333,0.00003455283,0.000008894004,0.00002274638,0.0003277137,0.000009644219,0.001661926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183016,"threshold_uncertainty_score":0.00395757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432707965965196,"score_gpt":0.2817261972726698,"score_spread":0.2673991176130178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}