{"id":"W2117475296","doi":"10.1007/s00125-014-3295-8","title":"Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions","year":2014,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Banting and Best Diabetes Centre, University of Toronto; Novo Nordisk; University of Toronto","keywords":"PDX1; Pancreas; Beta cell; Biology; Apoptosis; Cell biology; Glucose homeostasis; Ubiquitin ligase; Streptozotocin; Endocrinology; Diabetes mellitus; Internal medicine; Ubiquitin; Genetics; Medicine; Islet; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004088854,0.0006817338,0.0004574624,0.001200578,0.0002752329,0.0005772565,0.0005096751,0.0007124745,0.002005068],"category_scores_gemma":[0.0002483075,0.0003903474,0.0003997352,0.000294936,0.0008064704,0.0009767807,0.0003138866,0.001723036,0.0003983492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003032971,"about_ca_system_score_gemma":0.0002004652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002303977,"about_ca_topic_score_gemma":0.000360202,"domain_scores_codex":[0.9995925,0.00005762246,0.00003169754,0.00009749265,0.00008611372,0.000134598],"domain_scores_gemma":[0.9995863,0.00005136182,0.0001322323,0.00006708395,0.00002799525,0.0001350106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001131904,0.0001028063,0.0003543864,0.00003210303,0.00001157084,0.00007175576,0.00002170984,0.00005782322,0.9960573,0.0003496708,0.00004005939,0.001768908],"study_design_scores_gemma":[0.00005851018,0.0005020076,0.00430622,0.000009261169,0.00004561029,0.0002719292,0.00006332483,0.000574876,0.992901,0.0002117455,0.001048575,0.000007172102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940286,0.001687898,0.002434796,0.0002781082,0.00004449323,0.00001667381,0.0003390889,0.0001403557,0.00103014],"genre_scores_gemma":[0.9927096,0.0008987292,0.001883601,0.0001192718,0.00002190099,0.00004290202,0.0003802828,0.00006839724,0.003875285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005068,"threshold_uncertainty_score":0.006707609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290639461417344,"score_gpt":0.2435122659058431,"score_spread":0.2306058712916696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}