{"id":"W2117494325","doi":"10.1074/jbc.m005387200","title":"Nramp 2 (DCT1/DMT1) Expressed at the Plasma Membrane Transports Iron and Other Divalent Cations into a Calcein-accessible Cytoplasmic Pool","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Chemistry; Calcein; DMT1; Divalent; Biophysics; Gene isoform; Biochemistry; Cytoplasm; Membrane; Transferrin; Transporter; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002104913,0.0001677563,0.000333192,0.00002096688,0.0001363547,0.00001957872,0.0001494456,0.0001816989,0.004405796],"category_scores_gemma":[0.00006465023,0.00008871093,0.0001461116,0.00009474878,0.0002407354,0.00004971908,0.00002143828,0.0002966073,0.00001179078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003558425,"about_ca_system_score_gemma":0.0000722124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002109086,"about_ca_topic_score_gemma":0.000005184265,"domain_scores_codex":[0.9989223,0.00003463739,0.0004241766,0.0001840345,0.0002257031,0.0002091234],"domain_scores_gemma":[0.9993203,0.00007804846,0.0001673411,0.0001914221,0.00004606936,0.0001968284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001490505,0.0004756946,0.03118313,0.000296129,0.0000551942,0.0000883472,0.0005032463,0.00009627992,0.95548,0.00001672759,0.001590411,0.008724365],"study_design_scores_gemma":[0.007681744,0.0005359943,0.09829909,0.0002725214,0.0005169639,0.001585403,0.0009879401,0.00008405172,0.7693096,0.0004447157,0.1197419,0.0005400676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929033,0.002187398,0.00001461763,0.002004116,0.00004935867,0.0001127649,0.00001860424,0.00001477303,0.002695103],"genre_scores_gemma":[0.9956034,0.001321048,0.0001980801,0.000655218,0.0002114531,0.000007227486,0.00001324236,0.00001139714,0.001978879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1861704,"threshold_uncertainty_score":0.9965043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646286548155008,"score_gpt":0.2617769086116909,"score_spread":0.2453140431301408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}