{"id":"W2117502107","doi":"10.1124/pr.113.007450","title":"Idiosyncratic Adverse Drug Reactions: Current Concepts","year":2013,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":309,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Abacavir; Drug; Major histocompatibility complex; Immune system; Biology; Human leukocyte antigen; Mechanism (biology); Pharmacology; Computational biology; Immunology; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008778843,0.001970453,0.002894695,0.00330268,0.0002346981,0.001795041,0.001022947,0.001469601,0.005969313],"category_scores_gemma":[0.00120314,0.000424938,0.001103486,0.003176698,0.0005527736,0.001979589,0.001166145,0.001939411,0.00188845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004630381,"about_ca_system_score_gemma":0.001261415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006098496,"about_ca_topic_score_gemma":0.001745906,"domain_scores_codex":[0.9994335,0.0001059137,0.0001492282,0.00008064718,0.0001872694,0.00004338854],"domain_scores_gemma":[0.9989329,0.0004082097,0.0003897375,0.00002531615,0.0001626709,0.00008113183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001924179,0.0001159363,0.000314023,0.03458661,0.0002298971,0.0004001955,0.00005057693,0.0003657615,0.001476213,0.0007977486,0.02045113,0.9410195],"study_design_scores_gemma":[0.0002750016,0.0005121148,0.00313687,0.02080026,0.001866404,0.005891733,0.0002009663,0.0005036348,0.0008819207,0.002800272,0.9630378,0.00009294179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009086679,0.9991499,0.0001245684,0.0001019506,0.0001216534,0.000007956877,0.00001265872,0.000007511224,0.0003829336],"genre_scores_gemma":[0.0006298576,0.9983081,0.0002156602,0.0002316653,0.000293304,0.000007786341,0.00002246239,0.000001215117,0.0002900274],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005969313,"threshold_uncertainty_score":0.01996934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2452716020907198,"score_gpt":0.5063049541448696,"score_spread":0.2610333520541499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}