{"id":"W2117502107","doi":"10.1124/pr.113.007450","title":"Idiosyncratic Adverse Drug Reactions: Current Concepts","year":2013,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":309,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Abacavir; Drug; Major histocompatibility complex; Immune system; Biology; Human leukocyte antigen; Mechanism (biology); Pharmacology; Computational biology; Immunology; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001031039,0.001109939,0.005321024,0.0003087176,0.0002008337,0.00003622593,0.0004470726,0.0003929686,0.002981239],"category_scores_gemma":[0.00139867,0.0006871041,0.002568259,0.0009289827,0.0002157184,0.0002666856,0.0002099215,0.002762391,0.02840123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009434901,"about_ca_system_score_gemma":0.0006020294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009043603,"about_ca_topic_score_gemma":6.449723e-7,"domain_scores_codex":[0.993874,0.001259831,0.002469293,0.001102088,0.0005158544,0.0007789478],"domain_scores_gemma":[0.9958954,0.0007927468,0.001426948,0.0007894526,0.0001764876,0.0009189902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001584213,0.000472854,3.971392e-7,0.02345025,0.0002510878,0.00005656552,0.00001134165,1.236079e-7,0.00002447568,0.00008083748,0.02633085,0.9493197],"study_design_scores_gemma":[0.0005306157,0.00002647479,0.000003191757,0.02653048,0.00878496,0.0003435389,0.0000117674,0.000007281134,0.000003539491,0.00002288152,0.96314,0.0005952956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002322241,0.9677777,0.00001867393,0.000160526,0.002497487,0.0101776,0.00003341493,0.0002904368,0.01904187],"genre_scores_gemma":[0.000004515486,0.9866639,0.0005087911,0.0004368412,0.001362204,0.00479809,0.0002413901,0.00009814222,0.005886061],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9487243,"threshold_uncertainty_score":0.999558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2452716020907198,"score_gpt":0.5063049541448696,"score_spread":0.2610333520541499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}