{"id":"W2117506315","doi":"10.1128/jb.182.5.1410-1414.2000","title":"Influence of Mutations in the <i>mexR</i> Repressor Gene on Expression of the MexA-MexB-OprM Multidrug Efflux System of <i>Pseudomonas aeruginosa</i>","year":2000,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Pseudomonas aeruginosa; Efflux; Repressor; Mutant; Gene; Mutation; Multiple drug resistance; Genetics; Regulator gene; Pseudomonadales; Regulation of gene expression; Microbiology; Gene expression; Drug resistance; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004919026,0.0001553599,0.0004257754,0.00008312871,0.00003936244,0.00000452567,0.0006967699,0.0003197223,0.00001120393],"category_scores_gemma":[0.0001293676,0.00008991587,0.0001890947,0.0001598163,0.0003537793,0.000006349389,0.0000987747,0.0002366582,9.472924e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001342248,"about_ca_system_score_gemma":0.00009565354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003919081,"about_ca_topic_score_gemma":0.00001185562,"domain_scores_codex":[0.9981793,0.0003679946,0.0009180575,0.0001900581,0.0001636806,0.00018089],"domain_scores_gemma":[0.9982186,0.00008420483,0.0009153988,0.0005589775,0.0001913194,0.00003150302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003776565,0.0001402767,0.002642413,0.00004325809,0.00003484654,0.000003756876,0.0001643348,0.002399628,0.9934202,0.00003583671,0.00005786567,0.0006799242],"study_design_scores_gemma":[0.0007908273,0.0007525905,0.06404348,0.0001549479,0.00003339881,0.0001881049,0.0001078243,0.00001068438,0.9322596,0.00002497461,0.001553726,0.00007983614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989297,0.0002545753,0.000009046795,0.0002631138,0.0001586472,0.0002008202,0.00005039796,0.000001975041,0.0001317691],"genre_scores_gemma":[0.9989976,0.0003751428,0.0003655431,0.0001139318,0.00009986417,0.000006096219,0.000008734107,0.00001119632,0.00002193083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06140107,"threshold_uncertainty_score":0.3666663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005782569967241015,"score_gpt":0.2215866240917022,"score_spread":0.2158040541244612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}