{"id":"W2117514750","doi":"10.1158/1535-7163.mct-07-2376","title":"Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death<i>in vitro</i>and<i>in vivo</i>","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"In vivo; In vitro; Programmed cell death; Cancer research; Chemistry; Transient (computer programming); Cell culture; Cell biology; Biology; Apoptosis; Pharmacology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214228,0.0004268133,0.0003683938,0.00015627,0.0002102318,0.0002804419,0.0002352618,0.0002387631,0.001660442],"category_scores_gemma":[0.00006200939,0.0001598133,0.0004225981,0.0002181847,0.0002224653,0.0001701011,0.0001538017,0.0009015893,0.0004579244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004540438,"about_ca_system_score_gemma":0.0003632057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001651124,"about_ca_topic_score_gemma":0.003136896,"domain_scores_codex":[0.9997953,0.00003347987,0.000017256,0.00004135817,0.00004835251,0.00006430333],"domain_scores_gemma":[0.9999248,0.0000151982,0.00001587146,0.00001578451,0.000007327317,0.00002114295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003291686,0.0001192304,0.0001790215,0.00003037365,0.00001194934,0.00004391226,0.000018822,0.00009864243,0.9980551,0.00009786116,0.00008163261,0.0009343385],"study_design_scores_gemma":[0.000008537771,0.0004733326,0.001122111,0.000001843948,0.000009494307,0.00007085223,0.00001543365,0.0003005222,0.9972042,0.000008254156,0.0007834463,0.000001773243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931602,0.001494705,0.002032667,0.0001028008,0.00007057512,0.00005441518,0.0005882245,0.0001061548,0.002390223],"genre_scores_gemma":[0.9891726,0.001493956,0.002878615,0.00006789043,0.00001178708,0.0001400969,0.001950876,0.00002372319,0.004260458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660442,"threshold_uncertainty_score":0.005554736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483581217287643,"score_gpt":0.2265443856456854,"score_spread":0.211708573472809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}