{"id":"W2117514750","doi":"10.1158/1535-7163.mct-07-2376","title":"Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death<i>in vitro</i>and<i>in vivo</i>","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"In vivo; In vitro; Programmed cell death; Cancer research; Chemistry; Transient (computer programming); Cell culture; Cell biology; Biology; Apoptosis; Pharmacology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009443455,0.0002390615,0.0002794694,0.00009902658,0.00003815358,0.000008455974,0.0001227381,0.0001660073,0.000004015971],"category_scores_gemma":[0.000002669838,0.0002410872,0.00006984678,0.0001408245,0.00008141535,0.000004210534,0.00006092913,0.0001085863,5.556765e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002429541,"about_ca_system_score_gemma":0.0001049538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002163581,"about_ca_topic_score_gemma":0.00017988,"domain_scores_codex":[0.9987058,0.00007763776,0.0003036385,0.0004228493,0.000162734,0.0003273327],"domain_scores_gemma":[0.9994811,0.00001060734,0.00006417245,0.0002864025,0.00004115001,0.0001165757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002324457,0.0001737454,0.008730759,0.00005922625,0.00002241276,0.00007387796,0.0006521225,0.0000992269,0.9893718,0.000007289121,0.00003963783,0.0005375039],"study_design_scores_gemma":[0.002048797,0.0002913341,0.00351153,0.00002575662,0.0000288972,0.00001571629,0.00007320155,0.00002549424,0.986689,0.00001101756,0.007016531,0.0002627171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893619,0.00949884,0.0002866399,0.00009836577,0.000132917,0.0003311046,0.00006761809,0.000006071438,0.0002164932],"genre_scores_gemma":[0.9962505,0.002028603,0.000452512,0.001025992,0.0000472871,0.00004750503,0.000009545479,0.00003888332,0.00009917729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007470237,"threshold_uncertainty_score":0.9831252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483581217287643,"score_gpt":0.2265443856456854,"score_spread":0.211708573472809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}