{"id":"W2117556987","doi":"10.1093/emboj/cdf338","title":"Telencephalon‐specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development","year":2002,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Neuroblast; Neurogenesis; Cell biology; Mitosis; Neural stem cell; Embryonic stem cell; Cell cycle; Retinoblastoma protein; Progenitor cell; Conditional gene knockout; Cerebrum; Cellular differentiation; Genetics; Stem cell; Neuroscience; Apoptosis; Central nervous system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936276,0.0008366904,0.0006666594,0.0009991337,0.0003472494,0.0006785907,0.0006612357,0.0006838705,0.004150363],"category_scores_gemma":[0.0002099413,0.0005775454,0.0004595781,0.0002842262,0.001041505,0.0005167301,0.000412733,0.0014672,0.001415053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005643126,"about_ca_system_score_gemma":0.0003143438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00201863,"about_ca_topic_score_gemma":0.004105213,"domain_scores_codex":[0.9997044,0.00001725887,0.00003094926,0.00008144367,0.0001075937,0.00005829855],"domain_scores_gemma":[0.9996248,0.00005887861,0.000163873,0.0000478708,0.00001761883,0.00008692571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001110037,0.000005437714,0.000114592,0.00001879838,0.000008391597,0.0001668031,0.00001382662,0.00007227337,0.9987158,0.0001435506,0.00005010887,0.0005795027],"study_design_scores_gemma":[0.00002540211,0.00004468988,0.007981461,0.000007175306,0.0000377342,0.001105249,0.00004731644,0.0004725527,0.9884748,0.0001078834,0.001686565,0.00000921549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836829,0.002273469,0.005766794,0.0003567212,0.0001048445,0.00002706642,0.003077599,0.0006962061,0.004014321],"genre_scores_gemma":[0.9707007,0.001554426,0.006083469,0.0001331336,0.00002779279,0.00005516587,0.002045726,0.0005030516,0.01889645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004150363,"threshold_uncertainty_score":0.01388437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02773840623871006,"score_gpt":0.2419435818522705,"score_spread":0.2142051756135605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}