{"id":"W2117585236","doi":"10.1371/journal.pone.0087645","title":"Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; McGill University and Génome Québec Innovation Centre","funders":"National Institute for Health and Care Research; National Institute of General Medical Sciences; Qatar National Research Fund; Japan Society for the Promotion of Science; U.S. Public Health Service; Japan Science and Technology Agency; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Versus Arthritis; Fonds National de la Recherche Luxembourg; Canadian Institutes of Health Research; Burroughs Wellcome Fund","keywords":"Genetics; Population; Allele frequency; Pedigree chart; Allele; Candidate gene; Biology; Locus (genetics); Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004006493,0.0002256526,0.0006052145,0.0001196843,0.00008891766,0.00008554097,0.0008309961,0.0001233782,0.0002048384],"category_scores_gemma":[0.001462559,0.0001951841,0.0000218248,0.0001956123,0.0002012377,0.0004262661,0.000442734,0.0002471055,0.00009282674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008284312,"about_ca_system_score_gemma":0.001480084,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2454349,"about_ca_topic_score_gemma":0.02573216,"domain_scores_codex":[0.9969624,0.0002422359,0.0005652356,0.0008847562,0.001043033,0.0003023168],"domain_scores_gemma":[0.9952503,0.0002977287,0.0003109091,0.003675893,0.0002537589,0.000211436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002541116,0.001728989,0.05201622,0.0002297795,0.001943929,0.0003225609,0.001815506,0.00007802198,0.9200172,0.00001792686,0.0009971323,0.0182916],"study_design_scores_gemma":[0.0192365,0.0009737245,0.1062512,0.003248079,0.000819426,0.0001078395,0.0004771801,0.7978009,0.06963275,0.0008561983,0.00006985146,0.0005263466],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900956,0.001794387,0.002409927,0.00008175049,0.00004467212,0.0006528217,0.004787752,0.0000830785,0.00005004371],"genre_scores_gemma":[0.9473855,0.002458057,0.02014099,0.00008707462,0.0001727077,0.00002311527,0.02962853,0.00005018481,0.00005383639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8503845,"threshold_uncertainty_score":0.9920457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09977477278799306,"score_gpt":0.3187639287372409,"score_spread":0.2189891559492478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}