{"id":"W2117608041","doi":"10.1128/mcb.01120-07","title":"Acetylation-Induced Transcription Is Required for Active DNA Demethylation in Methylation-Silenced Genes","year":2007,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; DNA demethylation; RNA polymerase II; Molecular biology; DNA methylation; Epigenetics of physical exercise; Transcription (linguistics); Demethylation; Promoter; Histone methylation; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007170386,0.0002137718,0.0002138869,0.0001728364,0.0001045463,0.00001786863,0.0001026489,0.0004333036,0.000009440971],"category_scores_gemma":[0.00009163894,0.0002251237,0.0001164306,0.0001784921,0.00006390054,0.00001092436,0.00003240957,0.00008657822,0.000001825335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002576205,"about_ca_system_score_gemma":0.00004332006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004179062,"about_ca_topic_score_gemma":0.00008890269,"domain_scores_codex":[0.9984791,0.0001290963,0.0004047521,0.0005469254,0.00009652125,0.000343577],"domain_scores_gemma":[0.9993498,0.00004691205,0.0001384143,0.0002410638,0.0001394403,0.00008435643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001811073,0.00003473034,0.002140674,0.0000150753,0.00003790347,0.000001217154,0.0001827026,0.00003943525,0.9578338,0.0006580755,0.000002451286,0.03887282],"study_design_scores_gemma":[0.00104957,0.0003875404,0.0039334,0.00000685922,0.00003031259,9.894035e-7,0.0001097539,0.0003605929,0.9878227,0.003320019,0.002718489,0.0002597522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7345647,0.00281809,0.2617087,0.000120225,0.0001335819,0.0004372449,0.00001687021,0.000009719866,0.000190897],"genre_scores_gemma":[0.9962285,0.000239643,0.002502041,0.0001479679,0.0001222768,0.00004959084,0.0006319475,0.0000292645,0.00004882793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2616638,"threshold_uncertainty_score":0.9180277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0190083041015091,"score_gpt":0.2858272350463915,"score_spread":0.2668189309448824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}