{"id":"W2117633457","doi":"10.2174/1381612053381701","title":"Cytokines as a Precipitant of Depressive Illness: Animal and Human Studies","year":2005,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":213,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Proinflammatory cytokine; Antidepressant; Cytokine; Medicine; Anhedonia; Neurotransmitter; Internal medicine; Endocrinology; Sickness behavior; Animal models of depression; Immunology; Dopamine; Inflammation; Central nervous system; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002649779,0.000636217,0.001616539,0.0002244454,0.0002083311,0.00005695138,0.000542743,0.0001724802,0.0001064399],"category_scores_gemma":[0.001006443,0.0004729045,0.000329137,0.0003989334,0.0008272508,0.0001698762,0.0003467895,0.0006121428,0.00006419195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006115699,"about_ca_system_score_gemma":0.0001383461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.858815e-7,"about_ca_topic_score_gemma":1.552672e-7,"domain_scores_codex":[0.9965023,0.0008138889,0.0008010618,0.0009201067,0.0004427124,0.0005199632],"domain_scores_gemma":[0.9974571,0.001527186,0.0003967963,0.0003057076,0.00006903316,0.0002441498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004439941,0.0003142038,9.359513e-7,0.009489442,0.00008205833,0.00002418561,0.0001718118,6.624379e-7,0.001116414,0.003696249,0.0008510033,0.9842086],"study_design_scores_gemma":[0.0006858869,0.0002298616,0.000002611741,0.006240306,0.0006485063,0.00006869908,0.00003041997,0.00002862119,0.006004187,0.0004542962,0.9849683,0.0006383085],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001551359,0.9974379,0.0001013188,0.00003239301,0.0004288457,0.001466815,0.00006326288,0.00009029144,0.0002240561],"genre_scores_gemma":[0.003891536,0.9953992,0.00005401349,0.000061798,0.0002597773,0.0002197927,0.000005273515,0.0000596825,0.0000489434],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9841173,"threshold_uncertainty_score":0.9997723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3399554514491655,"score_gpt":0.4952558110698303,"score_spread":0.1553003596206648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}