{"id":"W2117654575","doi":"10.1261/rna.70306","title":"Pokeweed antiviral protein depurinates the sarcin/ricin loop of the rRNA prior to binding of aminoacyl-tRNA to the ribosomal A-site","year":2006,"lang":"en","type":"article","venue":"RNA","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; York University; Department of Mechanical Engineering, University of Texas at Austin; Ontario Innovation Trust","keywords":"Depurination; Ricin; Ribosome; Biology; Ribosome-inactivating protein; Aminoacyl-tRNA; Ribosomal RNA; Biochemistry; Protein biosynthesis; Elongation factor; Transfer RNA; RNA; Translation (biology); A-site; Ribosomal protein; Molecular biology; Binding site; DNA; Messenger RNA; Toxin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004497609,0.0002150224,0.0003107846,0.0001009759,0.0005149324,0.00001839893,0.0008335726,0.0001245565,0.00008725727],"category_scores_gemma":[0.0001078944,0.0001057616,0.0001768067,0.0004507996,0.0001784551,0.00006027018,0.000491268,0.0003146081,0.0001949177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000325178,"about_ca_system_score_gemma":0.00005302428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298795,"about_ca_topic_score_gemma":0.0002758456,"domain_scores_codex":[0.9984936,0.0002725876,0.0004410752,0.0002567138,0.00009972631,0.0004363539],"domain_scores_gemma":[0.9988874,0.0001115116,0.0002412213,0.0006644477,0.00008087898,0.00001458352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001225187,0.0001038741,0.001656241,0.00001509879,0.00005781282,0.000001331048,0.0007067982,0.00001904259,0.9908044,0.00212323,0.0007591783,0.003630501],"study_design_scores_gemma":[0.0004556243,0.0002592603,0.06686649,0.0001013335,0.00003773471,0.00001367918,0.0002374415,0.000004322573,0.9228043,0.0001293499,0.008953137,0.00013733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946136,0.0006568621,0.0001253954,0.001780544,0.0004448346,0.001228661,0.00008256762,0.00002558348,0.001041982],"genre_scores_gemma":[0.9913979,0.000005333488,0.0001680184,0.0002023291,0.0000548607,0.00004616423,0.000007772759,0.00002358424,0.008093996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06800007,"threshold_uncertainty_score":0.4312832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006834752012494416,"score_gpt":0.2077790918602371,"score_spread":0.2009443398477427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}