{"id":"W2117671780","doi":"10.1186/ar2066","title":"Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid peroxidation end product 4-hydroxynonenal","year":2006,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"","keywords":"Osteoblast; 4-Hydroxynonenal; Osteocalcin; p38 mitogen-activated protein kinases; Endocrinology; Internal medicine; Lipid peroxidation; Chemistry; CREB; MAPK/ERK pathway; Phosphorylation; Alkaline phosphatase; Bone remodeling; Prostaglandin E2; Signal transduction; Oxidative stress; Biology; Biochemistry; Transcription factor; Medicine; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002929201,0.0003247886,0.0003280056,0.0002383948,0.0001621622,0.0002309601,0.00008468957,0.0002149763,0.0008241864],"category_scores_gemma":[0.0001564981,0.0001940843,0.0003408921,0.0001933586,0.0002093034,0.0001726782,0.0001600034,0.0003526616,0.0002345181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321352,"about_ca_system_score_gemma":0.0002004606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006629179,"about_ca_topic_score_gemma":0.00111956,"domain_scores_codex":[0.99977,0.00005432451,0.00002217121,0.00003414175,0.00007346994,0.00004595383],"domain_scores_gemma":[0.9999217,0.00001601143,0.00001652588,0.00001210189,0.00001757475,0.00001608581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004589819,0.00006440853,0.0005952952,0.00003344879,0.000007075564,0.00006810499,0.0000278741,0.0000242652,0.9977114,0.00001403501,0.000008235891,0.0009869422],"study_design_scores_gemma":[0.0001063793,0.002321375,0.03101524,0.000007952132,0.00004978807,0.0003401751,0.0001620581,0.0007007216,0.9638656,0.00006575957,0.001353383,0.00001165105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946621,0.003381052,0.001095777,0.00004928453,0.00002583299,0.00003483682,0.0001553409,0.000009707799,0.000586072],"genre_scores_gemma":[0.9940109,0.002018859,0.001728905,0.00005406177,0.0000201563,0.00007398578,0.0004140418,0.000004775211,0.001674368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008241864,"threshold_uncertainty_score":0.002757192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02350788090054014,"score_gpt":0.3251763843004502,"score_spread":0.3016685033999101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}