{"id":"W2117698323","doi":"10.1128/iai.73.12.7844-7852.2005","title":"<i>Helicobacter pylori</i> Activates Myosin Light-Chain Kinase To Disrupt Claudin-4 and Claudin-5 and Increase Epithelial Permeability","year":2005,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; University of Calgary","funders":"","keywords":"Myosin light-chain kinase; Tight junction; Biology; Claudin; Helicobacter pylori; Occludin; Paracellular transport; CagA; Cell biology; Myosin; Microbiology; Permeability (electromagnetism); Virulence; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005503214,0.0003483217,0.0004918935,0.000214522,0.0004611439,0.00006353405,0.00004879405,0.0002199701,0.00006770607],"category_scores_gemma":[0.0005587458,0.0002991646,0.00006680078,0.000219912,0.0003237619,0.0003059598,0.0002651286,0.000683765,0.00003321961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351777,"about_ca_system_score_gemma":0.00003235795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086198,"about_ca_topic_score_gemma":0.0006564434,"domain_scores_codex":[0.9982732,0.0002911036,0.0003962313,0.0004722934,0.0001486247,0.0004185516],"domain_scores_gemma":[0.998765,0.0001545955,0.0001002444,0.0003744235,0.0001776666,0.0004280716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001219886,0.0004835635,0.8394976,0.00008434924,0.0002585409,0.0000103943,0.002301355,0.000001272369,0.1116946,0.00002459334,0.0005099955,0.04391389],"study_design_scores_gemma":[0.002443919,0.001009717,0.9431003,0.00009360348,0.0001742821,0.0002267938,0.0002034404,0.00004268805,0.01239158,0.00003437325,0.04003944,0.0002398229],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878625,0.0003021702,0.00005410128,0.01026284,0.0002025652,0.0005295288,0.0000332809,0.0001138103,0.0006392425],"genre_scores_gemma":[0.9960021,0.0007361789,0.0001844693,0.002528623,0.0002676838,0.00004637916,0.00001801194,0.00002785347,0.0001887326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1036028,"threshold_uncertainty_score":0.9999461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214302735290525,"score_gpt":0.261182227684204,"score_spread":0.2490392003312987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}