{"id":"W2117701806","doi":"10.1158/0008-5472.can-08-1952","title":"Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Leptin; Endocrinology; Epidermal growth factor receptor; Internal medicine; Cancer research; Breast cancer; Leptin receptor; Protein kinase B; Lapatinib; Insulin receptor; Phosphorylation; Autocrine signalling; Growth factor receptor; Biology; Chemistry; Medicine; Cancer; Receptor; Insulin; Cell biology; Insulin resistance; Trastuzumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113434,0.0005180889,0.0002688268,0.0002019381,0.0001308796,0.0002759716,0.0001259854,0.0001825312,0.0009994716],"category_scores_gemma":[0.00007323864,0.0001637571,0.0003127559,0.0001726084,0.0001174728,0.0001900303,0.0002466405,0.0004928593,0.000219607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001975916,"about_ca_system_score_gemma":0.000221206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003730094,"about_ca_topic_score_gemma":0.00104589,"domain_scores_codex":[0.9998342,0.00003601988,0.00001256984,0.00002214207,0.00004569556,0.00004949811],"domain_scores_gemma":[0.9999615,0.000004586693,0.0000143261,0.000002371525,0.000005400216,0.00001191324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00019388,0.00005683825,0.0004502123,0.0001359408,0.00001703644,0.0001853691,0.00001515012,0.00007666686,0.9954479,0.0001077011,0.00009846858,0.003214722],"study_design_scores_gemma":[0.0001104104,0.001482296,0.03221105,0.00004855743,0.0001176599,0.001224485,0.0001301667,0.003323268,0.9509515,0.000181726,0.01019652,0.00002240036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741424,0.01912378,0.002704525,0.0004031385,0.0001139722,0.00004907155,0.0002489192,0.0000707903,0.003143447],"genre_scores_gemma":[0.9887314,0.006811276,0.00202339,0.0001398686,0.00002801002,0.00006558778,0.000218399,0.000005344047,0.001976575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009994716,"threshold_uncertainty_score":0.003343582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07022020547242627,"score_gpt":0.3269190220914856,"score_spread":0.2566988166190594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}