{"id":"W2117722841","doi":"10.1128/aac.46.6.1880-1886.2002","title":"Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases","year":2002,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Food Inspection Agency","keywords":"Bacillus cereus; Cereus; Stereochemistry; Chemistry; Active site; Antibacterial activity; Enzyme; Microbiology; Biology; Biochemistry; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162975,0.0003859471,0.0003752645,0.000375056,0.0001180811,0.0003060907,0.0003121804,0.0002096767,0.001687175],"category_scores_gemma":[0.0001881964,0.0001180252,0.0002480817,0.0002724745,0.0001875135,0.0001954595,0.0002492615,0.0003403159,0.0005996176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107032,"about_ca_system_score_gemma":0.0001751527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004106882,"about_ca_topic_score_gemma":0.001190588,"domain_scores_codex":[0.9999275,0.00001035831,0.000006632519,0.00001309237,0.00002745395,0.00001497399],"domain_scores_gemma":[0.9999021,0.00001122462,0.00002079443,0.000007963855,0.00002144126,0.00003645543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005056256,0.0002162397,0.001103601,0.0003373827,0.0000509285,0.0005944797,0.00005994214,0.000822652,0.9374639,0.0002997247,0.0006078975,0.05793764],"study_design_scores_gemma":[0.0005987142,0.01131139,0.01731635,0.0001293511,0.0002318897,0.007114483,0.0001128854,0.002696747,0.9042063,0.0003878665,0.05582816,0.00006596992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9546235,0.02667443,0.006546096,0.0002761799,0.0001151586,0.0002945575,0.00158194,0.0002134542,0.009674737],"genre_scores_gemma":[0.9636036,0.01553588,0.01070029,0.000350557,0.00007362503,0.0001327982,0.003877989,0.00002235296,0.005702805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001687175,"threshold_uncertainty_score":0.005644143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007673313653550348,"score_gpt":0.2228955918791474,"score_spread":0.2152222782255971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}