{"id":"W2117722841","doi":"10.1128/aac.46.6.1880-1886.2002","title":"Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases","year":2002,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Food Inspection Agency","keywords":"Bacillus cereus; Cereus; Stereochemistry; Chemistry; Active site; Antibacterial activity; Enzyme; Microbiology; Biology; Biochemistry; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007569212,0.0001381823,0.0002475244,0.00005141398,0.00002980288,0.00001119556,0.0001260246,0.00008282519,0.00003210696],"category_scores_gemma":[0.0000300244,0.0001219461,0.00008943964,0.000124653,0.0002133848,0.00001264697,0.00003397025,0.0000384027,0.000001062474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000048916,"about_ca_system_score_gemma":0.00001573783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000274018,"about_ca_topic_score_gemma":0.000003902884,"domain_scores_codex":[0.9990664,0.00002864374,0.0004174875,0.0002510021,0.0001039324,0.0001325581],"domain_scores_gemma":[0.9992738,0.000004164005,0.0003651466,0.0002469628,0.00008784127,0.00002203059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001818102,0.0002045443,0.006634883,0.0001254033,0.0001133645,6.658271e-7,0.0001283422,0.000001077768,0.9888398,0.00002653961,0.00247411,0.001269453],"study_design_scores_gemma":[0.0005362832,0.0001690755,0.0281191,0.00003751917,0.0000250353,0.00001225817,0.0000402729,0.00000593312,0.9685183,0.00001806015,0.002404517,0.000113711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985774,0.0003659484,0.0000203248,0.0006067802,0.0001402537,0.0001930448,0.00002410104,0.00000432147,0.0000678725],"genre_scores_gemma":[0.9952309,0.003263017,0.0001823074,0.0001393034,0.00006760682,0.000001010319,0.00002904481,0.00001758895,0.001069197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02148422,"threshold_uncertainty_score":0.4972818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007673313653550348,"score_gpt":0.2228955918791474,"score_spread":0.2152222782255971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}