{"id":"W2117743221","doi":"10.1073/pnas.2232515100","title":"Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":319,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Canadian Stroke Network; ALS Association; Muscular Dystrophy Association; Parkinson's Disease Foundation; U.S. Department of Defense","keywords":"Dopaminergic; Cyclin-dependent kinase; Cyclin-dependent kinase 5; MPTP; Kinase; Biology; Mediator; LRRK2; Dopamine; Regulator; Neuroscience; Parkinson's disease; Cyclin-dependent kinase 2; Cell biology; Protein kinase A; Disease; Medicine; Internal medicine; Cell cycle; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758031,0.0006686801,0.0003373178,0.000846177,0.0002926122,0.0003546737,0.0002784891,0.0005849311,0.001790642],"category_scores_gemma":[0.0001305925,0.0002715145,0.0002882341,0.000232107,0.0003643614,0.0003018829,0.000235276,0.0009869537,0.0003404669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005374621,"about_ca_system_score_gemma":0.000231371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009215135,"about_ca_topic_score_gemma":0.001688791,"domain_scores_codex":[0.999821,0.00002603333,0.00001592289,0.00004771541,0.00005750392,0.00003182979],"domain_scores_gemma":[0.9998602,0.00001739011,0.00004630103,0.0000103502,0.000009003967,0.00005679996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002902864,0.0000849541,0.0007817447,0.00007056463,0.00002242763,0.000448225,0.00002155892,0.0001168467,0.9955643,0.0004729184,0.0001534269,0.001972753],"study_design_scores_gemma":[0.0001466411,0.0011542,0.02165266,0.00004403501,0.0001229434,0.003048012,0.00007865128,0.003623819,0.9618719,0.0008012904,0.007443317,0.00001251577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855072,0.005399373,0.004272114,0.0005625024,0.00007309864,0.00004999854,0.0008624752,0.0002900372,0.002983261],"genre_scores_gemma":[0.9902879,0.001969927,0.002077611,0.0001084642,0.00001794157,0.00004997271,0.0006462033,0.00002860734,0.004813459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001790642,"threshold_uncertainty_score":0.005990326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07675963280458468,"score_gpt":0.3481535302163796,"score_spread":0.2713938974117949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}