{"id":"W2117779687","doi":"10.1136/ard.2009.111179","title":"Hormonal replacement therapy may reduce the risk for RA in women with early arthritis who carry HLA-DRB1 *01 and/or *04 alleles by protecting against the production of anti-CCP: results from the ESPOIR cohort","year":2009,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Merck Sharp and Dohme; Institut National de la Santé et de la Recherche Médicale","keywords":"Medicine; Menopause; Rheumatoid arthritis; Menarche; Cohort; Hormone replacement therapy (female-to-male); Internal medicine; Allele; Pregnancy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009014368,0.0005329255,0.0004917504,0.0002653608,0.0002152714,0.0004290062,0.0002878683,0.0004498462,0.002673657],"category_scores_gemma":[0.001300954,0.0002489518,0.0007820789,0.000334533,0.0001829687,0.00025318,0.0001613786,0.0003741134,0.0002410601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001153128,"about_ca_system_score_gemma":0.0002084718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003589599,"about_ca_topic_score_gemma":0.003651512,"domain_scores_codex":[0.9997697,0.00009791932,0.00001502874,0.00003862617,0.00002885615,0.00004991038],"domain_scores_gemma":[0.9996257,0.00013561,0.00007907711,0.00007146931,0.00002810461,0.00006002722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01878859,0.0007093015,0.9429037,0.0000821976,0.001138441,0.0005731664,0.0002483201,0.0002140065,0.006443877,0.00009516446,0.0005783552,0.02822486],"study_design_scores_gemma":[0.001076867,0.003255064,0.9908645,0.00002996236,0.001331117,0.0006847779,0.0002567524,0.0001967506,0.0007182196,0.0001353714,0.001438281,0.00001238527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973685,0.001006546,0.0001059911,0.000104245,0.00002404937,0.000008187022,0.0002198059,0.000007084189,0.001155656],"genre_scores_gemma":[0.998319,0.0004476719,0.0001447953,0.00009471121,0.00002777243,0.000004940003,0.000219351,0.000003059882,0.0007386989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003589599,"threshold_uncertainty_score":0.008944273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02279480295119968,"score_gpt":0.2846768860598368,"score_spread":0.2618820831086371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}