{"id":"W2117786106","doi":"10.1093/emboj/cdf447","title":"Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability","year":2002,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; McMaster University","keywords":"Biology; Lipophosphoglycan; Mutant; Endoplasmic reticulum; Glycoconjugate; Cell biology; Virulence; Leishmania; Biochemistry; Leishmania donovani; Parasite hosting; Genetics; Gene; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0026366,0.0003020355,0.0007114167,0.0002027478,0.0005616889,0.0001076111,0.0006248983,0.0001113227,0.0005340884],"category_scores_gemma":[0.003637409,0.000197109,0.0002866756,0.000447645,0.0005112548,0.0002399801,0.0001503476,0.0008372178,0.0001096421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004353592,"about_ca_system_score_gemma":0.0001124009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002590639,"about_ca_topic_score_gemma":0.0001581888,"domain_scores_codex":[0.9968383,0.0003742508,0.0007599329,0.0004433409,0.0006585118,0.0009257016],"domain_scores_gemma":[0.9969032,0.001459823,0.0002688326,0.0007176485,0.0003671172,0.0002834239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01114533,0.00452619,0.3420255,0.0009677151,0.002349113,0.002122349,0.01188341,0.0001680408,0.333532,0.0012404,0.05967334,0.2303665],"study_design_scores_gemma":[0.007984726,0.002385556,0.794199,0.0009992055,0.0006303352,0.00631837,0.002812253,0.008702808,0.1576636,0.008517099,0.008628632,0.001158336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797088,0.001159536,0.0003246223,0.01606485,0.0001369505,0.001060867,0.00004370788,0.00006078903,0.001439866],"genre_scores_gemma":[0.9956347,0.001456286,0.0008831817,0.0005728744,0.0003082354,0.000270625,0.000001801223,0.00004396959,0.0008283238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4521735,"threshold_uncertainty_score":0.8037873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06085686595147576,"score_gpt":0.3217835841890868,"score_spread":0.260926718237611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}