{"id":"W2117803125","doi":"10.3892/or.2015.4184","title":"Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation","year":2015,"lang":"en","type":"article","venue":"Oncology Reports","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McMaster University","funders":"McMaster University","keywords":"Radioresistance; Cancer research; In vivo; Small hairpin RNA; Chemistry; Oncogene; Cell; Cell culture; Biology; Molecular biology; Cell cycle; Gene knockdown; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178247,0.0002903767,0.0004213465,0.0001789551,0.0001184188,0.0002102915,0.0002180578,0.0002238552,0.001272519],"category_scores_gemma":[0.00009023297,0.0001391637,0.0002751314,0.0001487939,0.0001786496,0.0001335478,0.0001350854,0.0006405447,0.0002924766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000235539,"about_ca_system_score_gemma":0.0002555563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001230648,"about_ca_topic_score_gemma":0.002197206,"domain_scores_codex":[0.9998521,0.00001682189,0.0000159931,0.00002823495,0.00004574046,0.00004117107],"domain_scores_gemma":[0.9999391,0.00001136754,0.00001513037,0.00000918262,0.0000079875,0.00001721915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001071994,0.00006323442,0.0001768049,0.00003699545,0.000009372158,0.00002513282,0.00001045816,0.00005964928,0.9985318,0.00004346191,0.00006538283,0.0008704615],"study_design_scores_gemma":[0.00001937539,0.0007643938,0.004140601,0.000004356544,0.00001812867,0.0001200321,0.00002062327,0.0006879702,0.9922809,0.00002089819,0.001919281,0.000003413606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928377,0.002263895,0.001596932,0.000130673,0.00008675877,0.00006634039,0.0003518368,0.0001320004,0.002533879],"genre_scores_gemma":[0.9924056,0.001836921,0.001581785,0.00005411476,0.00001479802,0.00005713336,0.0005300919,0.00001366173,0.003505941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272519,"threshold_uncertainty_score":0.004257023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600662841138072,"score_gpt":0.256829658805474,"score_spread":0.2408230303940933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}